Indomethacin
Indications
Indomethacin is used for:
Rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis (degenerative joint disease), gout, acute non-articular rheumatism (bursitis, synovitis, tendinitis).
Adult Dose
Oral
Inflammatory/Rheumatoid Disorders
Immediate release: 25-50 mg PO q8-12hr; not to exceed 200 mg/day
Extended release: 75-150 mg/day PO in single daily dose or divided q12hr; not to exceed 150 mg/day
Bursitis/Tendinitis
Immediate-release: 75-150 mg/day PO divided q6-8hr
Extended-release: 75-150 mg/day PO in single daily dose or divided q12hr
Acute Gouty Arthritis
50 mg PO q8hr for 3-5 days; reduced once pain is under control
Rectal
Pain and inflammation associated with musculoskeletal and joint disorders
Adult: As supp: 100 mg to be inserted at night and repeated in the morning if necessary.
Child Dose
Inflammatory/Rheumatoid Disorders
<2 years: Safety and efficacy not established
2-14 years: 1-2 mg/kg/day PO divided q6-12hr; not to exceed 4 mg/kg/day or 150-200 mg/day
>14 years: 25-50 mg IR PO q8-12hr; not to exceed 200 mg/day;
75-150 mg/day ER PO in single daily dose or divided q12hr; not to exceed 150 mg/day
Renal Dose
Administration
Take with food to avoid gastrointestinal (GI) effects
Contra Indications
Indomethacin is contraindicated in patients with ulcer, gastritis, active ulcerative colitis, and should be used with caution in patients with a history of these disorders. It is also contraindicated in previously hypersensitive patient.
Precautions
Patient w/ known CV disease or risk factors for CV disease, fluid retention, history of GI disease (e.g. bleeding or ulcers), history of mental depression or other psychiatric disorder, epilepsy, or parkinsonian syndrome; existing infection that is adequately controlled. May mask signs and symptoms of infection. Hepatic and renal impairment. Elderly, childn. Pregnancy and lactation.
Lactation: Drug enters breast milk; use not recommended (American Academy of Pediatrics committee states that drug is compatible with nursing)
Pregnancy-Lactation
Interactions
May increase plasma levels of methotrexate. Increased risk of GI bleeding w/ warfarin. May reduce hypotensive effects of hydralazine, furosemide, ?-blockers (e.g. atenolol, propranolol, oxprenolol), or thiazide diuretics. Increased risk of hyperkalaemia w/ K-sparing diuretics, ACE inhibitors, K supplements. May increase nephrotoxic effects of ciclosporin or triamterene. Increase plasma concentration w/ probenecid. May increase plasma levels of aminoglycoside (e.g. amikacin, gentamicin) in premature neonates. May enhance antipsychotic effect (e.g. severe drowsiness and confusion) of haloperidol. Al- or Mg-containing antacids may reduce GI disorders of indometacin.
Potentially Fatal: Diflunisal decreases renal clearance and increases plasma concentrations of indometacin which leads to fatal GI haemorrhage.
Adverse Effects
Side effects of Indomethacin :
>10%
Transient renal insufficiency (40%),Jaundice (<15%),Elevated liver function test values (≤15%),Headache (12%)
1-10%
Dizziness (3-9%),Dyspepsia (3-9%),Epigastric pain (3-9%),Indigestion (3-9%),Nausea (3-9%)
Symptomatic upper GI ulcers, gross bleeding/perforation (4% of patients treated for 1 year; 1% of patients treated for 3-6 months).
Abnormal pain/cramps/distress (<3%),Constipation (1-3%),Depression (1-3%),Diarrhea (1-3%),Fatigue (1-3%),Somnolence (1-3%),Tinnitus (1-3%),Vertigo (1-3%)
<1%
Acute interstitial nephritis with hematuria/proteinuria,Acute respiratory distress,Agranulocytosis,Angioedema,Aplastic anemia,Asthma,Bone marrow depression,Congestive heart failure (CHF),Hemolytic anemia,Leukopenia,Macular and morbilliform eruptions,Pulmonary edema,Thrombocytopenia,Thrombocytopenic purpura,Ulcerative stomatitis,Urticaria
Mechanism of Action
Indometacin, an indole acetic acid derivative has anti-inflammatory, analgesic and antipyretic actions. It reversibly inhibits cyclooxygenase-1 and -2 (COX-1 and -2) enzymes, thus resulting in reduced synthesis of prostaglandin precursors.