Iopamidol

Indications

Iopamidol is used for: Radiographic contrast medium for diagnostic procedures

Adult Dose

Angiography Cerebral Arteriography 300 mg/mL: 8-12 mL intra-arterial, may repeat, not to exceed 90 mL Coronary Arteriography 370 mg/mL: 2-10 mL IV; monitor EKG; not to exceed 200 mL Coronary Ventriculography 370 mg/mL: 25-50 mL IV; monitor EKG; not to exceed 200 mL Selective Visceral Arteriography 370 mg/mL: Up to 50 mL IV; not to exceed 225 mL Selective Visceral Aortography 370 mg/mL: Up to 50 mL IV; not to exceed 225 mL Computed Tomography CECT of the Head, Body 300 mg/mL: 100-200 mL IV; not to exceed 200 mL Urography Excretory Urography 300 mg/mL: 50 mL IV OR 370 mg/mL: 40 mL IV

Child Dose

Angiocardiography For 370 mg/mL: <2 years: 10-15 mL IV, not to exceed 40 mL total 2-9 years: 15-30 mL IV, not to exceed 50 mL (2-4 years) or 100 mL (5-9 years) 10-18 years: 20-50 mL IV, not to exceed 125 mL Computed Tomography CECT of the Head, Body 300 mg/mL: 1-3 mL/kg IV; not to exceed 30 g of iodine Urography Excretory Urography 300 mg/mL: 1-3 mL/kg IV; not to exceed 30 g of iodine

Renal Dose

Administration

Contra Indications

Not for intrathecal use.

Precautions

May inhibit blood coagulation. Multiple myeloma or other paraproteinaemia. Sickle-cell disease. Known or suspected phaeochromocytoma (monitor closely). Hyperthyroidism. Ensure adequate hydration. History of a previous sensitivity to a contrast medium, sensitivity to iodine, bronchial asthma, hay fever and food allergy. Monitor patients with CHF. Avoid angiography in patients with homocystinuria. Severe arterial or venous disease. Severe renal impairment, combined renal and hepatic disease or anuria, especially when large doses are used. Pregnancy and lactation. Lactation: Excretion into breast milk unknown; not recommended

Pregnancy-Lactation

Interactions

Arrhythmias, arterial spasm, flushing, vasodilatation, angina, cardiopulmonary arrest; dizziness, confusion, paraesthesia, visual disturbances, seizure, paralysis, coma, temporary amnesia; inj site pain, pallor, periorbital and facial oedema; coughing, sneezing, rhinitis, asthma, apnoea, laryngeal oedema, chest tightness; watery itchy eyes, lachrymation, conjunctivitis; muscle spasm, involuntary leg movement; tremors, malaise; severe retching and choking, abdominal pain; urogenital pain, haematuria. Potentially Fatal: Severe anaphylactoid reactions.

Adverse Effects

Side effects of Iopamidol : Arrhythmias, arterial spasm, flushing, vasodilatation, angina, cardiopulmonary arrest; dizziness, confusion, paraesthesia, visual disturbances, seizure, paralysis, coma, temporary amnesia; inj site pain, pallor, periorbital and facial oedema; coughing, sneezing, rhinitis, asthma, apnoea, laryngeal oedema, chest tightness; watery itchy eyes, lachrymation, conjunctivitis; muscle spasm, involuntary leg movement; tremors, malaise; severe retching and choking, abdominal pain; urogenital pain, haematuria. Potentially Fatal: Severe anaphylactoid reactions.

Mechanism of Action

Iopamidol is a nonionic iodinated radiographic contrast medium. It allows visualisation of internal body structures by opacifying the path of its flow.