Iopamidol
Indications
Iopamidol is used for:
Radiographic contrast medium for diagnostic procedures
Adult Dose
Angiography
Cerebral Arteriography
300 mg/mL: 8-12 mL intra-arterial, may repeat, not to exceed 90 mL
Coronary Arteriography
370 mg/mL: 2-10 mL IV; monitor EKG; not to exceed 200 mL
Coronary Ventriculography
370 mg/mL: 25-50 mL IV; monitor EKG; not to exceed 200 mL
Selective Visceral Arteriography
370 mg/mL: Up to 50 mL IV; not to exceed 225 mL
Selective Visceral Aortography
370 mg/mL: Up to 50 mL IV; not to exceed 225 mL
Computed Tomography
CECT of the Head, Body
300 mg/mL: 100-200 mL IV; not to exceed 200 mL
Urography
Excretory Urography
300 mg/mL: 50 mL IV OR
370 mg/mL: 40 mL IV
Child Dose
Angiocardiography
For 370 mg/mL:
<2 years: 10-15 mL IV, not to exceed 40 mL total
2-9 years: 15-30 mL IV, not to exceed 50 mL (2-4 years) or 100 mL (5-9 years)
10-18 years: 20-50 mL IV, not to exceed 125 mL
Computed Tomography
CECT of the Head, Body
300 mg/mL: 1-3 mL/kg IV; not to exceed 30 g of iodine
Urography
Excretory Urography
300 mg/mL: 1-3 mL/kg IV; not to exceed 30 g of iodine
Renal Dose
Administration
Contra Indications
Not for intrathecal use.
Precautions
May inhibit blood coagulation. Multiple myeloma or other paraproteinaemia. Sickle-cell disease. Known or suspected phaeochromocytoma (monitor closely). Hyperthyroidism. Ensure adequate hydration. History of a previous sensitivity to a contrast medium, sensitivity to iodine, bronchial asthma, hay fever and food allergy. Monitor patients with CHF. Avoid angiography in patients with homocystinuria. Severe arterial or venous disease. Severe renal impairment, combined renal and hepatic disease or anuria, especially when large doses are used. Pregnancy and lactation.
Lactation: Excretion into breast milk unknown; not recommended
Pregnancy-Lactation
Interactions
Arrhythmias, arterial spasm, flushing, vasodilatation, angina, cardiopulmonary arrest; dizziness, confusion, paraesthesia, visual disturbances, seizure, paralysis, coma, temporary amnesia; inj site pain, pallor, periorbital and facial oedema; coughing, sneezing, rhinitis, asthma, apnoea, laryngeal oedema, chest tightness; watery itchy eyes, lachrymation, conjunctivitis; muscle spasm, involuntary leg movement; tremors, malaise; severe retching and choking, abdominal pain; urogenital pain, haematuria.
Potentially Fatal: Severe anaphylactoid reactions.
Adverse Effects
Side effects of Iopamidol :
Arrhythmias, arterial spasm, flushing, vasodilatation, angina, cardiopulmonary arrest; dizziness, confusion, paraesthesia, visual disturbances, seizure, paralysis, coma, temporary amnesia; inj site pain, pallor, periorbital and facial oedema; coughing, sneezing, rhinitis, asthma, apnoea, laryngeal oedema, chest tightness; watery itchy eyes, lachrymation, conjunctivitis; muscle spasm, involuntary leg movement; tremors, malaise; severe retching and choking, abdominal pain; urogenital pain, haematuria.
Potentially Fatal: Severe anaphylactoid reactions.
Mechanism of Action
Iopamidol is a nonionic iodinated radiographic contrast medium. It allows visualisation of internal body structures by opacifying the path of its flow.