Iopromide

Indications

Iopromide is used for:

Adult Dose

Digital Subtraction Angiography 150 mg/mL, intra-arterial single injection dose Carotid arteries: 6-10 mL Vertebral arteries: 4-8 mL Aorta: 20-50 mL Major branches of the abdominal aorta: 2-20 mL Not to exceed 250 mL cumulative dose Cerebral Arteriography 300 mg/mL, intra-arterial single injection dose Carotid arteries: 3-12 mL Vertebral arteries: 4-12 mL Aortic arch injection (4-vessel): 20-50 mL Not to exceed 150 mL cumulative dose Peripheral Arteriography 300 mg/mL, intra-arterial single injection dose Subclavian or femoral artery: 5-40 mL Aortic bifurcation: 25-50 mL Not to exceed 250 mL cumulative dose Coronary Arteriography & Left Ventriculography 370 mg/mL, intra-arterial single injection dose Right or left coronary artery: 3-14 mL Left ventricle: 30-60 mL Not to exceed 225 mL cumulative dose Visceral Angiography 370 mg/mL, intra-arterial Use volume and infusion rate proportional to blood flow and related to the vascular and pathological characteristics of the specific vessels being studied Not to exceed 225 mL cumulative dose Peripheral Venography 240 mg/mL, IV Inject minimum volume necessary to visualize structures under examination Not to exceed 250 mL cumulative dose Excretory Urography 300 mg/mL, IV ~300 mg/kg, IV (with normal renal function) Not to exceed 100 mL cumulative dose Contrast Computed Tomography 300 mg/mL, IV Head: 50-200 mL Body (bolus injection): 50-200 mL Body (rapid infusion): 100-200 mL Not to exceed 200 mL cumulative dose 370 mg/mL, IV Head: 41-162 mL Body (bolus injection): 41-162 mL Body (rapid infusion): 81-162 mL Not to exceed 162 mL cumulative dose

Child Dose

Renal Dose

Administration

Hydrate patient adequately before and following administration Warm contrast solution to body temperature shortly before administration to improve tolerability Do not exceed cumulative iodine dose of 86 grams Carefully individualize volume and concentration Dosage volume and administration rate vary depending on injection site; see prescribing information for specific details

Contra Indications

Not for intrathecal use.

Precautions

Ensure adequate hydration. Increased risk of immune reaction with previous contrast sensitivity, allergy to iodine, asthma, hay fever and food allergies. Renal impairment, combined renal and hepatic disease, combined renal and cardiac disease, DM, sickle-cell disease, severe thyrotoxicosis, myelomatosis or anuria. Pregnancy and lactation.

Pregnancy-Lactation

Interactions

Increased risk of delayed hypersensitivity with interleukins. May cause renal impairment and induce lactic acidosis with metformin.

Adverse Effects

Side effects of Iopromide : Vasodilatation, chest pain, hypertension, headache, pain, dizziness, nausea, vomiting, abnormal taste, urinary urgency, inj site reactions, back pain, abnormal vision. Potentially Fatal: Anaphylaxis and thrombosis.

Mechanism of Action

Iopromide is a nonionic iodinated radiographic contrast medium. It allows visualisation of internal body structures by opacifying the path of its flow.