Lafutidine

Indications

Lafutidine is used for: Gastric and duodenal ulcers; Stomal ulcers, Gastric mucosal lesions

Adult Dose

Oral Gastric and duodenal ulcers; Stomal ulcers Adult: 10 mg bid, once after breakfast, once after evening meal or before sleeping. Adjust dose according to patient's age and symptoms. Gastric mucosal lesions Adult: 10 mg once daily, after evening meal or before sleeping. Adjust dose according to patient's age and symptoms. Pre-anaesthetic medication Adult: 10 mg before sleeping on the day before operation, and 10 mg 2 hr before introduction of anaesthetic on the day of operation. Elderly: Dose reduction or increase in dosing interval may be needed. Hepatic impairment: Dose reduction or increase in dosing interval may be needed.

Child Dose

Renal Dose

Renal impairment: Dose reduction or increase in dosing interval may be needed.

Administration

Contra Indications

Lactation.

Precautions

Hepatic and renal impairment. Elderly.

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Lafutidine : Constipation, hyperuricaemia, increase in LFT and total bilirubin, gynaecomastia, anorexia, hallucinations. Potentially Fatal: Anaphylactic reactions, blood dyscrasias (e.g. agranulocytosis, thrombocytopenia).

Mechanism of Action

Lafutidine is a histamine H2-antagonist with gastroprotective activity. It is used in the treatment of gastric ulcers and before general anaesthesia to reduce the incidence of aspiration pneumonia.