Levosulpiride

Indications

Levosulpiride is used for: Gastro-oesophageal reflux disease, Irritable bowel syndrome, Dyspepsia

Adult Dose

Oral Gastro-oesophageal reflux disease, Irritable bowel syndrome, Dyspepsia Adult: 25 mg tid. Elderly: Dose reductions may be necessary.

Child Dose

Renal Dose

Administration

Contra Indications

Phaeochromocytoma, epilepsy, manic states, hyperprolactinaemia, mammary dysplasia, malignant mastopathies, cardiac impairment. GI bleeding, mechanical obstruction or perforation.

Precautions

May impair ability to drive or operate machinery. Pregnancy and lactation.

Pregnancy-Lactation

Interactions

Reduced bioavailability with sucralfate, aluminium- and magnesium-containing antacids. Effect on GI motility may be antagonised by anticholinergic agents, narcotics and analgesics. Avoid alcohol.

Adverse Effects

Side effects of Levosulpiride : Amenorrhoea, gynaecomastia, galactorrhoea, changes in libido. Potentially Fatal: Neuroleptic malignant syndrome.

Mechanism of Action

Levosulpiride is a substituted benzamide, which exerts antidopaminergic (selective dopamine D2 receptors) activity on both central and peripheral levels. It is an atypical neuroleptic and a prokinetic agent.