Levosulpiride
Indications
Levosulpiride is used for:
Gastro-oesophageal reflux disease, Irritable bowel syndrome, Dyspepsia
Adult Dose
Oral
Gastro-oesophageal reflux disease, Irritable bowel syndrome, Dyspepsia
Adult: 25 mg tid.
Elderly: Dose reductions may be necessary.
Child Dose
Renal Dose
Administration
Contra Indications
Phaeochromocytoma, epilepsy, manic states, hyperprolactinaemia, mammary dysplasia, malignant mastopathies, cardiac impairment. GI bleeding, mechanical obstruction or perforation.
Precautions
May impair ability to drive or operate machinery. Pregnancy and lactation.
Pregnancy-Lactation
Interactions
Reduced bioavailability with sucralfate, aluminium- and magnesium-containing antacids. Effect on GI motility may be antagonised by anticholinergic agents, narcotics and analgesics. Avoid alcohol.
Adverse Effects
Side effects of Levosulpiride :
Amenorrhoea, gynaecomastia, galactorrhoea, changes in libido.
Potentially Fatal: Neuroleptic malignant syndrome.
Mechanism of Action
Levosulpiride is a substituted benzamide, which exerts antidopaminergic (selective dopamine D2 receptors) activity on both central and peripheral levels. It is an atypical neuroleptic and a prokinetic agent.