Magnesium Valproate
Indications
Magnesium Valproate is used for:
Seizures
Migraine
Mania
Adult Dose
Oral
Tablet
1 tab bid
CR tablet: Once daily
Child Dose
Renal Dose
Administration
Tablet may be taken with or without food
Contra Indications
Hypersensitivity
Liver disease, significant hepatic impairment
Precautions
Probability of thrombocytopenia increases significantly at total trough valproate plasma concentrations exceed 110 mcg/mL in females and 135 mcg/mL in males
Bleeding and other hematopoietic disorders may occur; monitor platelet counts and coagulation tests
Hepatotoxic (age <2 years, higher risk of fatal hepatotoxicity); evaluate high risk populations and monitor serum liver tests; risk factors include organic brain disease, mental retardation with severe seizure disorders, congenital metabolic disorders, and patients on multiple anticonvulsants; discontinue immediately with signs/symptoms of significant or suspected impairment
This may make patient feel dizzy, sleepy, tired, or decrease alertness. Caution, not to drive.
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Magnesium Valproate :
Common
Headache
Dizziness
Blurred vision
Loss of appetite
Nausea
Vomiting
Sleepiness
Hair loss
Weight gain
Double vision
Diarrhea
Coordination impaired
Tremor
Weakness
Stomach pain
Increased appetite