Mefenamic Acid + Paracetamol
Indications
Mefenamic Acid + Paracetamol is used for:
It is indicated for pain and fever in children.
Adult Dose
Child Dose
Children 6m-2 years age: 1 tsf t.i.d.
2-5 years age : 1- 2 tsf t.i.d.
Renal Dose
Administration
Contra Indications
Hypersensitivity to Paracetamol or constituent of this preparation.
Patients with severe hepatic dysfunction
Precautions
Paracetamol should be given with care to patients with impaired kidney or liver function and patients taking other drugs that affect the liver.
Pregnancy-Lactation
Interactions
Paracetamol may reduce serum levels w/ anticonvulsants (e.g. phenytoin, barbiturates, carbamazepine). May enhance the anticoagulant effect of warfarin and other coumarins w/ prolonged use. Accelerated absorption w/ metoclopramide and domperidone. May increase serum levels w/ probenecid. May increase serum levels of chloramphenicol. May reduce absorption w/ colestyramine w/in 1 hr of admin. May cause severe hypothermia w/ phenothiazine.
Mefenamic acid
Concomitant use w/ CYP2C9 isoenzyme inhibitors may alter safety and efficacy of mefenamic acid. May enhance methotrexate toxicity. Reduced BP response to ACE inhibitors or angiotensin II receptor antagonists. Increased risk of serious GI events w/ aspirin. May reduce the natriuretic effects of furosemide or thiazide diuretics. Reduced renal lithium clearance and elevated plasma lithium levels. May enhance anticoagulant effect of warfarin.
Adverse Effects
Side effects of Mefenamic Acid + Paracetamol :
The most commonly reported adverse effects are feeling or being sick, hypersensitivity reactions, skin rashes, diarrhea, nausea
Mechanism of Action
Paracetamol exhibits analgesic action by peripheral blockage of pain impulse generation. It produces antipyresis by inhibiting the hypothalamic heat-regulating centre. Its weak anti-inflammatory activity is related to inhibition of prostaglandin synthesis in the CNS.
Mefenamic acid, an anthranilic acid derivative, is a prototypical NSAID. It reversibly inhibits the cyclooxygenase-1 and -2 (COX-1 and -2) enzymes, thus resulting in reduced synthesis of prostaglandin precursors. It has analgesic and antipyretic properties w/ minor anti-inflammatory activity.