Memantine + Donepezi
Indications
Memantine + Donepezi is used for:
Used for the symptomatic treatment of alzheimer's disease.
Adult Dose
Tablet
Once a day, mostly in the evening just before bedtime.
Child Dose
Renal Dose
Administration
Take it with food to avoid an upset stomach and drink plenty of fluids to keep yourself hydrated while taking this medicine.
Contra Indications
contraindicated in patients who are allergic to Memantine, Donepezil or any of its constituents.
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Memantine + Donepezi :
Common
Nausea
Vomiting
Loss of appetite
Diarrhea
Headache
Dizziness
Bleeding under the skin
Mechanism of Action
Donepezil reversibly and noncompetitively inhibits centrally-active acetylcholinesterase that is responsible for the hydrolysis of acetylcholine, resulting to increased concentration of acetylcholine in the CNS.
Memantine, a derivative of amantadine, is a noncompetitive N-methyl-D-aspartate (NMDA)-receptor antagonist which binds preferentially to NMDA-receptor-operated cation channels. It blocks the action of glutamate, the principal excitatory neurotransmitter in the CNS. Glutamate may contribute to the pathogenesis of Alzheimer's disease by overstimulating various glutamate receptors resulting in excitotoxicity and neuronal cell death.