Mesterolone

Indications

Mesterolone is used for: Androgen deficiency ; Infertility due to hypogonadism

Adult Dose

Oral Androgen deficiency ; Infertility due to hypogonadism Adult: Initially, 75-100 mg daily in divided doses. Maintenance: 50-75 mg daily in divided doses.

Child Dose

Renal Dose

Administration

Contra Indications

Prostatic or breast carcinoma. Previous or existing hepatic tumours. Pregnancy and lactation.

Precautions

Regularly examine the prostate and breast during treatment. CV disorders, renal or hepatic impairment, epilepsy, migraine, DM or other conditions that may be exacerbated by the possible fluid retention or oedema. Skeletal metastases (risk of hypercalcaemia). Children. Monitor skeletal maturation during therapy.

Pregnancy-Lactation

Interactions

Enhances effects of ciclosporin, antidiabetics, levothyroxine, anticoagulants e.g. warfarin. Resistance to the effects of neuromuscular blockers may occur.

Adverse Effects

Side effects of Mesterolone : Frequent or persistent erections. Potentially Fatal: Malignant liver tumours.

Mechanism of Action

Mesterolone is an androgen with less inhibitory effects on intrinsic testicular function compared to testosterone.