Metadoxine

Indications

Metadoxine is used for: Alcoholic fatty liver

Adult Dose

Oral Acute alcohol intoxication Adult: 500-1000 mg daily. Alcoholic fatty liver Adult: 1000 mg daily. Supportive treatment of acute and chronic liver diseases Adult: 1000 mg daily. Parenteral Acute alcohol intoxication Adult: 300-600 mg daily IM/IV. Alcoholic fatty liver Adult: 300 mg daily IM/IV. Supportive treatment of acute and chronic liver diseases Adult: 300 mg daily IM/IV.

Child Dose

Renal Dose

Administration

Contra Indications

Pregnancy and lactation.

Precautions

Pregnancy-Lactation

Interactions

May reduce effects of levodopa; administer levodopa with a dopa-decarboxylase inhibitor to minimise interaction.

Adverse Effects

Side effects of Metadoxine :

Mechanism of Action

Metadoxine enhances the elimination of alcohol from blood and tissues, which leads to faster recovery from alcohol intoxication. In the early stages of alcoholic liver disease, metadoxine has been suggested to prevent the redox imbalance of the hepatocytes and to prevent TNF-alpha induction.