Metformin + Voglibose
Indications
Metformin + Voglibose is used for:
Used in the treatment of type 2 diabetes mellitus.
Adult Dose
Oral
Diabetes mellitus
Adult: 1 tab 1-3 times daily.
Child Dose
Renal Dose
Administration
Should be taken with food.
Contra Indications
Hypersensitivity
Precautions
This medicine should be used with caution in patients with a known history of kidney & liver disease due to the increased risk of worsening of the patient's condition. This medicine is not recommended for use in patients with any gastrointestinal diseases like inflammatory bowel disease, colonic ulceration, partial intestinal obstruction, or any chronic intestinal disease.
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Metformin + Voglibose :
Flatulence; abdominal distension; nausea, diarrhoea; loss of appetite, stomach pain; skin reactions; hypoglycemia; increased LFT.
Potentially Fatal: Hepatotoxicity.
Mechanism of Action
Voligbose has general properties similar to acarbose and selectively inhibits α-glucosidase in the enteric canal, delaying the digestion and absorption of carbohydrate, thereby suppressing sharp increase in post-prandial plasma glucose.
Metformin is a biguanide w/ antihyperglycaemic effects, lowering both basal and postprandial plasma glucose. It decreases hepatic glucose production by inhibiting gluconeogenesis and glycogenolysis; delays intestinal absorption of glucose; and enhances insulin sensitivity by increasing peripheral glucose uptake and utilisation.