Metronidazole 0.75% Vag prep
Indications
Metronidazole 0.75% Vag prep is used for:
Bacterial vaginosis (also known as non-specific vaginitis, anaerobic vaginosis or gardnerella vaginitis).
Adult Dose
Topical/Cutaneous
Bacterial vaginosis
Adult: As 0.75% gel: Apply to affected area intravaginally one applicatorful once daily or bid for 5 days.
Child Dose
Renal Dose
Administration
Contra Indications
Metronidazole is contraindicated in patients with a history of hypersensitivity to Metronidazole or other Nitroimidazole derivatives.
Precautions
Metronidazole should be given with caution in the following conditions- anaemia or other blood disorders, liver disease, disease of the nervous system, seizures etc.
Lactation: Excreted in human milk; caution advised
Pregnancy-Lactation
Interactions
Concurrent use w/ disulfiram may produce psychotic reactions. May potentiate the effect of oral anticoagulants. May increase risk of lithium toxicity. May reduce the renal clearance resulting to increased toxicity of 5-fluorouracil. May increase serum levels of ciclosporin. May increase plasma levels of busulfan resulting to severe busulfan toxicity. Enhanced metabolism w/ phenobarbital and phenytoin resulting to decreased serum concentrations.
Adverse Effects
Side effects of Metronidazole 0.75% Vag prep :
>10%
Bacterial infection (12%)
1-10%
Headache (7%),Pruritus (6%),Abdominal pain (5%),Nausea (3%),Dysmenorrhea (3%),Pharyngitis (2%),Rash (1%),Diarrhea (1%),Breast pain (1%),Metrorrhagia (1%)
Mechanism of Action
Metronidazole is converted to reduction products that interact w/ DNA to cause destruction of helical DNA structure and strand leading to a protein synthesis inhibition and cell death in susceptible organisms. It is active against most anaerobic protozoa, some gm+ve, gm-ve and facultative anaerobes.