Nepafenac 0.1% Eye prep

Indications

Nepafenac 0.1% Eye prep is used for: Occular pain and inflammation, Cystoid macular edema

Adult Dose

Prevention & treatment of post-op pain & inflammation Instill 1 drop 3 times daily 1 day prior to cataract surgery and continued on the day of surgery and through the first 2 weeks of the post-operative period. Prevention of post-operative macular oedema in diabetic patients Instill 1 drop 3 times daily 1 day before surgery and continued on the day of surgery and through the first 6 weeks of the post-operative period.

Child Dose

<10 years old: Safety and efficacy not established

Renal Dose

Administration

Contra Indications

Contraindicated in patients with previously demonstrated hypersensitivity to any of the ingredients in the formulation or to other NSAIDs.

Precautions

Nepafenac should be used with caution in patients with known bleeding tendencies or who are receiving medications which may prolong bleeding time. Lactation: use caution

Pregnancy-Lactation

Interactions

Topical NSAIDs & corticosteroids. May increase the risk of haemorrhage w/ drugs that prolong bleeding time.

Adverse Effects

Side effects of Nepafenac 0.1% Eye prep : 1-10% Capsular opacity,Decr visual acuity,Foreign body sensation,Increased IOP,Sticky sensation,Conjunctival edema,Corneal edema,Dry eye,Headache,HTN,Lid margin crusting,N/V,Ocular discomfort,Ocular hyperemia,Ocular pain,Ocular pruritus,Photophobia.Tearing,Vitreous detachment

Mechanism of Action

Non-steroidal anti-inflammatory prodrug, converted to amfenac which putatively inhibits prostaglandin biosynthesis.