Phenylephrine + Triprolidine

Indications

Phenylephrine + Triprolidine is used for: Cough and common cold

Adult Dose

Oral Cough and common cold Adult: 10 ml 4 -6 hrly, up to 4 times daily;

Child Dose

Renal Dose

Administration

Contra Indications

Severe hypertension or coronary artery disease. Patient at risk of respiratory failure. Avoid use in patients where cough is associated with asthma or with excessive secretion. Concurrent use or within 2 wk of stopping MAOIs.

Precautions

Severe hepatic impairment, severe or moderate renal impairment. Hypertension, heart disease, DM, hyperthyroidism, increased intra-ocular pressure, prostatic hypertrophy. May impair ability to drive or operate machinery. Pregnancy and lactation.

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Phenylephrine + Triprolidine : Nausea, vomiting, dry mouth, nose and throat, GI disturbances, skin rashes, drowsiness, sleep disturbance, tachycardia, urinary retention. Rarely, hallucinations.

Mechanism of Action

Triprolidine is a potent competitive histamine H1-receptor antagonist with mild sedating and antimuscarinic properties. Phenylephrine is a vasoconstrictor and a decongestant that relieves symptoms resulting from irritation of upper respiratory tract tissue. It shrinks swollen mucous membranes, reduces nasal congestion and tissue hyperemia.