Phytomenadione (Vitamin K1)

Indications

Phytomenadione (Vitamin K1) is used for: Vitamin K deficiency, Over-anticoagulation, Vitamin K deficiency bleeding

Adult Dose

Oral Vitamin K deficiency due to drugs or malabsorption Adult: 10-40 mg daily. Over-anticoagulation Adult: Up to 5 mg may be used. Dose depends on INR and degree of haemorrhage. Intravenous Over-anticoagulation Adult: 0.5-5 mg via slow IV inj. Dose depends on INR and degree of haemorrhage.

Child Dose

Intramuscular Prophylaxis of vitamin K deficiency bleeding in neonates Child: Neonate: 0.5-1 mg, given as a single dose via IM inj. Alternatively, 2 mg may be given orally, followed by a 2nd dose of 2 mg after 4-7 days. Parenteral Vitamin K deficiency bleeding in neonates Child: Infant: 1 mg by IV/IM/SC inj, further doses may be given if necessary

Renal Dose

Administration

May be taken with or without food.

Contra Indications

Hypersensitivity.

Precautions

Increased risk of severe haemolytic anaemia in neonates after large doses; severe hepatic impairment; pregnancy. Premature neonates weighing <2.5 kg. Lactation: Excreted in breast milk; use caution

Pregnancy-Lactation

Interactions

Decreased effect of oral anticoagulants.

Adverse Effects

Side effects of Phytomenadione (Vitamin K1) : Anaphylaxis, dyspnoea, cyanosis, pain, swelling, phloebitis at the Inj site, diaphoresis, dizziness, hypotension (rare), allergic reactions after SC and IM inj.

Mechanism of Action

Phytomenadione promotes hepatic synthesis of clotting factors. It is a naturally occurring compound that is used to prevent and treat haemorrhages related to vitamin K deficiency.