Piracetam + Citicoline
Indications
Piracetam + Citicoline is used for:
Used in the treatment of stroke
Adult Dose
The usual dosage of this tablet for slow thinking skills due to old age is 1000-2000 mg per day.
For chronic cerebrovascular disease the recommended dosage is 600 mg per day.
For ischemic stroke, it is 500-2000 mg of per day starting within the first 24 hours of stroke.
Child Dose
Renal Dose
Administration
It can be taken with or after food. Adequate amounts of fluids should be consumed while taking this medicine.
Contra Indications
Known history of allergy or any other ingredients
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Piracetam + Citicoline :
Weight gain, Hyperactivity, Stomach pain, Nervousness, Diarrhea, Decreased blood pressure
Mechanism of Action
Piracetam is a GABA derivative classified as a nootropic agent. The exact mechanism of action is not yet fully elucidated however, it has neuronal and vascular properties. It exerts neuronal effect by protecting the cerebral cortex from various insults (e.g. hypoxia, intoxications). It also has vascular effects on platelets, RBC, and vessel walls by inhibiting platelet aggregation, improves erythrocyte deformability and reduces blood viscosity.
Citicoline is a naturally occurring endogenous nucleoside involved in the biosynthesis of lecithin. It increases the synthesis of phosphatidylcholine (main neuronal membrane phospholipid) and enhances acetylcholine production. It is also claimed that it increases blood flow and oxygen consumption in the brain. Synonym: CDP-choline, cytidine diphosphate.