Prednisolone Acetate + Neomycin Sulphate E/E prep
Indications
Prednisolone Acetate + Neomycin Sulphate E/E prep is used for:
Allergic and inflammatory conditions of the eye & ear.
Adult Dose
Conjunctivitis
Adult: Instill 1-2 drops into the affected eye(s) 2-4 times daily.
Otic/Aural
Allergic and inflammatory conditions of the ear
Adult:1-2 drops into the affected ear 3-4 times daily.
Child Dose
Conjunctivitis
Child: Instill 1-2 drops into the affected eye(s) 2-4 times daily.
Otic/Aural
Allergic and inflammatory conditions of the ear
Child:1-2 drops into the affected ear 3-4 times daily.
Renal Dose
Administration
Contra Indications
Epithelial defect, glaucoma, herpes, vaccinia, varicella, and other viral diseases of cornea or conjunctiva, mycobacterial infection of eye, fungal diseases of ocular structures, hypersensitivity to any ingredients
Precautions
Prolonged use of corticosteroids may result in damage to the optic nerve and defects in vision. If this product is used for longer period of time, intraocular pressure should be routinely monitored.
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Prednisolone Acetate + Neomycin Sulphate E/E prep :
Ophthalmic: Raised IOP and reduced visual function.
Ear: Discomfort & pain in ear.
Fungal and viral infections of the cornea are particularly may develop coincidentally with long-term applications of steroid.
Mechanism of Action
Prednisolone decreases inflammation by inhibition of migration of polymorphonuclear leukocytes and reversal of increased capillary permeability. It suppresses the immune system by reducing the activity and production of the lymphocytes and eosinophils.
Neomycin is an aminoglycoside antibiotic. It binds to 30S ribosomal subunits of bacterial ribosome thus inhibiting protein synthesis and generating errors in genetic code transcription causing cell death. It acts against many gram-negative aerobes and some gram-positive aerobes. It lacks activity against fungi, viruses and most anaerobic bacteria.