Retapamulin 1% Topical
Indications
Retapamulin 1% Topical is used for:
Impetigo, Bacterial skin infections
Adult Dose
Topical/Cutaneous
Impetigo; Bacterial skin infections due to meticillin-susceptible, Staphylococcus aureus and Streptococcus pyogenes
Adult: As 1% ointment: Apply onto affected area bid for 5 days. Re-evaluate if there is no response after 3 days of treatment.
Total treatment area: <100 cm2 total body surface area.
Child Dose
Topical/Cutaneous
Impetigo; Bacterial skin infections due to meticillin-susceptible, Staphylococcus aureus and Streptococcus pyogenes
Child: As 1% ointment: >9 mth: Apply onto affected area bid for 5 days. Total treatment area: <2% of total body surface area.
Renal Dose
Administration
Contra Indications
Hypersensitivity.
Precautions
Discontinue use if skin irritation occurs. Prolonged use may result in fungal or bacterial superinfection. Re-evaluate if there is no response within 3 days. Children <9 mth. Pregnancy, lactation.
Lactation: use caution
Pregnancy-Lactation
Interactions
Concurrent application w/ other topical products to the same skin area is not recommended.
Adverse Effects
Side effects of Retapamulin 1% Topical :
1-10%
Application site irritation (2%)
Headache, pyrexia, pruritus, eczema, diarrhoea.
Mechanism of Action
Retapamulin is a pleuromutilin antibacterial isolated from the fungus Clitopilus passeckerianus. It is a bacteriostatic agent that works by inhibiting biosynthesis of bacterial protein by binding at protein L3 on the ribosomal 50S subunit. It also inhibits peptidyl transfer and blocks P-site interactions at this site, thus preventing the formation of active 50S ribosomal subunits.