Rupatadine
Indications
Rupatadine is used for:
Allergic rhinitis, Chronic idiopathic urticaria
Adult Dose
Oral
Allergic rhinitis; Chronic idiopathic urticaria
Adult: 10 mg once daily.
Child Dose
Oral
Allergic rhinitis; Chronic idiopathic urticaria
Child > 12 years: 10 mg once daily.
Renal Dose
Administration
Contra Indications
Hypersensitivity. Avoid alcohol.
Precautions
Renal or hepatic insufficiency. May impair ability to drive or operate machinery. Pregnancy, lactation. Elderly, children <12 yr.
Pregnancy-Lactation
Interactions
Increased CNS depressant effects when used with CNS depressants or alcohol.
Adverse Effects
Side effects of Rupatadine :
Headache, somnolence, fatigue/asthenia.
Mechanism of Action
Rupatadine acts as a long-acting, non-sedative antagonist at histaminergic H1-receptors. Rupatadine also antagonises the platelet-activating factor (PAF). Both histamine and PAF cause bronchoconstriction and lead to an increase in the vascular permeability, acting as mediators in the inflammatory process.