Silymarin
Indications
Silymarin is used for:
Chronic inflammatory diseases of the liver & hepatic cirrhosis.
Adult Dose
Oral
Hepatic diseases
Adult: Initially and In Serious Cases: 70-mg capsule: 2 caps 3 times daily.
140-mg capsule: 1 cap 3 times daily.
Child Dose
Renal Dose
Administration
Should be taken with food. Take after meals.
Contra Indications
Hypersensitivity, pregnancy, lactation.
Precautions
Children.
Pregnancy-Lactation
Interactions
Reduced lipid peroxidation w/ butyrophenones or phenothiazine. Antagonistic effect w/ yohimbine & phentolamine.
Adverse Effects
Side effects of Silymarin :
Occasional laxative effects. Abdominal bloating, diarrhoea, flatulence, loss of appetite, anorexia, nausea, stomach upset.
Mechanism of Action
Silymarin is an active principle from the fruit of Silybum marianum, which contains a mixture of flavonolignans. It reduces the turnover of membrane phospholipids and stabilises the cell membranes of hepatocytes. It has potent antioxidant action and prevents lipid peroxidation.