Strontium Renalate
Indications
Strontium Renalate is used for:
Postmenopausal osteoporosis
Adult Dose
Oral
Postmenopausal osteoporosis
Adult: 2 g daily.
Elderly: No dosage adjustment needed.
Hepatic impairment: No dosage adjustment needed.
Child Dose
Renal Dose
Renal impairment: No dosage adjustment needed.
CrCl (ml/min) Dosage Recommendation
<30 Not recommended.
Administration
Should be taken on an empty stomach. Take on an empty stomach between meals, preferably at bedtime at least 2 hr after food, milk, milk products or Ca supplements. Mix only w/ plain water & drink immediately.
Contra Indications
Patients w/ current or previous venous thromboembolic events including deep vein thrombosis and pulmonary embolism; temporary or permanent immobilisation due to post-surgical recovery or prolonged bed rest; current or history of ischaemic heart disease, peripheral arterial disease and/or cerebrovascular disease; uncontrolled HTN. Lactation.
Precautions
Not recommended for use in patients with CrCl <30 ml/min. Patients at increased risk of venous thromboembolism. Pregnancy.
Pregnancy-Lactation
Interactions
May reduce the absorption of oral tetracycline and quinolone antibiotics. Medicinal products containing Ca may reduce strontium ranelate bioavailability.
Adverse Effects
Side effects of Strontium Renalate :
Headache, GI disturbances, eczema, dermatitis; memory loss, consciousness disturbances, seizures, pyrexia, peripheral oedema, confusion, bronchial hyperreactivity. Angioedema, rash, urticaria, pruritus. Transient increases in creatine kinase activity (reversible).
Potentially Fatal: Toxic epidermal necrolysis, Stevens-Johnson syndrome, and drug rash w/ eosinophilia and systemic symptoms.
Mechanism of Action
Strontium ranelate stimulates bone formation, osteoblast precursor replication and collagen synthesis. Decreasing osteoclast differentiation and resorbing activity, it reduces bone resorption resulting in a rebalance of bone turnover in favour of bone formation.