Tetanus (Human Anti-tetanus) Immunoglobulin
Indications
Tetanus (Human Anti-tetanus) Immunoglobulin is used for:
Passive immunisation against Tetanus
Adult Dose
Intramuscular
Passive immunisation against tetanus
Adult: Prophylaxis: 250 units, increased to 500 units if >24 hr have elapsed or following burns or there is risk of heavy contamination.
Treatment: 150 units/kg, given by IM inj into multiple sites.
At the same time, but in a different extremity and with a separate syringe, active immunization with adsorved tetanus vaccine should be administered.
Child Dose
Intramuscular
Passive immunisation against tetanus
Child: Prophylaxis: 250 units, increased to 500 units if >24 hr have elapsed or following burns or there is risk of heavy contamination.
Treatment: 150 units/kg, given by IM inj into multiple sites.
At the same time, but in a different extremity and with a separate syringe, active immunization with adsorved tetanus vaccine should be administered.
Renal Dose
Administration
Contra Indications
Hypersensitivity homologous Ig-containing medicinal products particularly in patients w/ IgA deficiency & concurrent presence of Ab to IgA.
Precautions
Caution when used in patients with coagulation disorders or thrombocytopenia. Not to be used for IV admin. Pregnancy, lactation. If adsorbed tetanus vaccine is to be used concurrently, the vaccine and immunoglobulin should be administered with separate syringes and into different inj sites with separate lymphatic drainage. Patients should be observed for at least 20 minutes after admin.
Pregnancy-Lactation
Interactions
May reduce the efficacy of live vaccines.
Adverse Effects
Side effects of Tetanus (Human Anti-tetanus) Immunoglobulin :
Inj-site reactions: Pain, soreness and tenderness. Increased temperature, angioneurotic oedema, nephritic syndrome, anaphylactic shock.
Mechanism of Action
Tetanus immunoglobulin is used for passive immunisation against tetanus.