Tobramycin + Fluorometholone Eye prep
Indications
Tobramycin + Fluorometholone Eye prep is used for:
Bacterial eye infections, Ocular inflammation, Pink eye
Adult Dose
Ophthalmic
Ocular inflammation with suspected or confirmed bacterial infection
Adult: As Eye Drops: 1-2 drops instilled into the conjunctival sac(s) 4-6 hrly. Dosage may be increased to every 2 hrly during the initial 24-48 hr, decrease frequency gradually as improvement seen.
Child Dose
Renal Dose
Administration
Contra Indications
Viral infections of corneal and conjunctiva (e.g. epithelial herpes simplex keratitis, vaccinia, varicella). Mycobacterial or fungal infection of the eye.
Precautions
Pregnancy and lactation. Avoid prolonged use, monitor intraocular pressure routinely. Safety and effectiveness in children <2 yr not established.
Lactation: Excretion in milk unknown; use with caution
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Tobramycin + Fluorometholone Eye prep :
Hypersensitivity reactions, lid itching and swelling, conjunctival erythema, increase in intraocular pressure, glaucoma, optic nerve damage, posterior subcapsular cataract formation and delayed wound healing. Secondary infections especially after prolonged use.
Mechanism of Action
Tobramycin, an aminoglycoside antibiotic, has actions similar to that of gentamicin and is active against Staphylococci, Streptococci, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Proteus mirabilis, Morganella morganii, most Proteus vulgaris strains, Haemophilus influenzae and H. aegyptius, Moraxella lacunata, Acinetobacter calcoaceticus and some Neisseria species.
Fluorometholone, synthetic fluorinated corticosteroid; inhibits inflammatory response including edema, leukocyte migration, capillary dilation, and scar formation.