Anti-Thyrox Tablet
Carbimazole
10mg
Macleods Pharmaceuticals Pvt. Ltd.
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| Retail Price | 620.94 NPR |
Available as:
Indications
Anti-Thyrox Tablet is used for:
Grave's disease, Hyperthyroidism, Diabetic nephropathy, Preparation for thyroidectomy
Adult Dose
Oral
Hyperthyroidism, Adjunct to radio-iodine therapy, Grave's disease, Preparation for thyroidectomy
Adult: Initially, 20-60 mg daily as a single or divided dose, reduced gradually once euthyroidism is achieved. Maintenance: 5-15 mg daily for at least 1 yr or 18 mth.
Hepatic impairment: Severe: Contraindicated.
Child Dose
Oral
Hyperthyroidism; Adjunct to radio-iodine therapy; Preparation for thyroidectomy
Child: 3-17 yr Initially, 15 mg daily, adjusted according to response.
Renal Dose
Administration
May be taken with or without food. Take consistently w/ or w/o meals.
Contra Indications
Hyperthyroidism due to nodular goitre.
Precautions
Liver diseases, pregnancy, lactation.
Pregnancy-Lactation
Interactions
Increased serum levels of theophylline or may develop toxicity. May enhance the effect of anticoagulants.
Potentially Fatal: Increased sensitivity to warfarin in hyperthyroidism and careful control required as patient is rendered euthyroid.
Adverse Effects
Side effects of Carbimazole :
Mild leucopaenia, sore throat, mouth ulcers, fever, bruising, malaise; rarely cholestatic jaundice; nephrotic syndrome. Nausea, loss of taste, headache, arthralgia, alopoecia.
Potentially Fatal: Agranulocytosis, aplastic anaemia, hypoprothrombinaemia, neutropaenia; hypothyroidism and goitre.
Mechanism of Action
Carbimazole is metabolised to methimazole which is responsible for its antithyroid action. It blocks the production of thyroid hormones by inhibiting thyroid peroxidase.
Note
Anti-Thyrox 10mg Tablet manufactured by Macleods Pharmaceuticals Pvt. Ltd.. Its generic name is Carbimazole. Anti-Thyrox is availble in Nepal.
Farmaco Nepal drug index information on Anti-Thyrox Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.