Carvidon MR Tablet

Trimetazidine Dihydrochloride
35mg
Micro Labs Ltd.
Pack size
Dispensing mode
Source
Agent
Retail Price 19.20 NPR

Available as:

Indications

Carvidon MR Tablet is used for: Ischaemic heart disease, Angina pectoris; Coronary heart disease

Adult Dose

Oral Angina pectoris Adult: 40-60 mg daily in 2-3 divided doses. Modified-release tab: 35 mg bid.

Child Dose

Renal Dose

Renal impairment: CrCl (ml/min) Dosage Recommendation <30 Contraindicated. 30-60 20 mg bid. Modified-release: 35 mg once daily.

Administration

Should be taken with food.

Contra Indications

Hypersensitivity to Trimetazidine Dihydrochloride.

Precautions

Moderate renal impairment (CrCl 30-60 mL/min). Pregnancy. Patient Counselling May cause dizziness and drowsiness, if affected, do not drive or operate machinery. Although teratological studies have not shown any drug related adverse effects on the course and outcome of pregnancy, the use in pregnant women is not recommended. It is not known whetherTrimetazidine passes into breast milk or not. This medication should be used while breast feeding only if the potential benefits outweigh risks to the nursing infants.

Pregnancy-Lactation

Interactions

MAOIs, nifedipine. May potentiate the effects of other antianginals.

Adverse Effects

Side effects of Trimetazidine Dihydrochloride : Dizziness, headache, abdominal pain, dyspepsia, diarrhoea, nausea, vomiting, pruritus, rash, urticaria, asthenia. Rarely, tachycardia, palpitations, extrasystoles, orthostatic hypotension, arterial hypotension, flushing.

Mechanism of Action

Trimetazidine is a cellular acting anti-ischaemic agent. It has 3 main properties by which it acts as a cytoprotective agent. It inhibits the anaerobic glycolysis and fatty acid metabolism, thus allowing only aerobic glycolysis. This action helps to restore the energy balance in the cell. It inhibits acidosis and free radical accumulation in the cell. All these action help the cell to restore the normal ionic and metabolic balance.

Note

Carvidon MR 35mg Tablet manufactured by Micro Labs Ltd.. Its generic name is Trimetazidine Dihydrochloride. Carvidon MR is availble in Nepal. Farmaco Nepal drug index information on Carvidon MR Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Trimetazidine Dihydrochloride :