Trine Tablet
Trimetazidine Dihydrochloride
20mg
Time Pharmaceuticals Pvt. Ltd.
| Pack size | 1 |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 10.00 NPR |
Indications
Trine Tablet is used for:
Ischaemic heart disease, Angina pectoris; Coronary heart disease
Adult Dose
Oral
Angina pectoris
Adult: 40-60 mg daily in 2-3 divided doses.
Modified-release tab: 35 mg bid.
Child Dose
Renal Dose
Renal impairment:
CrCl (ml/min) Dosage Recommendation
<30 Contraindicated.
30-60 20 mg bid. Modified-release: 35 mg once daily.
Administration
Should be taken with food.
Contra Indications
Hypersensitivity to Trimetazidine Dihydrochloride.
Precautions
Moderate renal impairment (CrCl 30-60 mL/min). Pregnancy. Patient Counselling May cause dizziness and drowsiness, if affected, do not drive or operate machinery. Although teratological studies have not shown any drug related adverse effects on the course and outcome of pregnancy, the use in pregnant women is not recommended.
It is not known whetherTrimetazidine passes into breast milk or not. This medication should be used while breast feeding only if the potential benefits outweigh risks to the nursing infants.
Pregnancy-Lactation
Interactions
MAOIs, nifedipine. May potentiate the effects of other antianginals.
Adverse Effects
Side effects of Trimetazidine Dihydrochloride :
Dizziness, headache, abdominal pain, dyspepsia, diarrhoea, nausea, vomiting, pruritus, rash, urticaria, asthenia. Rarely, tachycardia, palpitations, extrasystoles, orthostatic hypotension, arterial hypotension, flushing.
Mechanism of Action
Trimetazidine is a cellular acting anti-ischaemic agent. It has 3 main properties by which it acts as a cytoprotective agent. It inhibits the anaerobic glycolysis and fatty acid metabolism, thus allowing only aerobic glycolysis. This action helps to restore the energy balance in the cell. It inhibits acidosis and free radical accumulation in the cell. All these action help the cell to restore the normal ionic and metabolic balance.
Note
Trine 20mg Tablet manufactured by Time Pharmaceuticals Pvt. Ltd.. Its generic name is Trimetazidine Dihydrochloride. Trine is availble in Nepal.
Farmaco Nepal drug index information on Trine Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.