Cerviprime Cream
Dinoprostone
.5mg
Astra Zeneca
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Indications
Cerviprime Cream is used for:
Cervical priming, induction and augmentation of labour
Adult Dose
Vaginal
Cervical Ripening
Gel: 2.5 mL (0.5 mg) in cervical canal using syringe and catheter; may repeat after 6 hr, maximum cumulative dose 1.5 mg/24 hr
Child Dose
Renal Dose
Administration
Contra Indications
Hypersensitivity to prostaglandins. Patients in whom oxytocics are generally contraindicated. History of pelvic inflammatory disease; active cardiac, pulmonary, renal or hepatic disease.
Precautions
Raised intraocular pressure. Previous caesarean section; history of asthma, epilepsy, hepatic or renal dysfunction, cardiovascular disease; pregnancy.
Pregnancy-Lactation
Interactions
Potentially Fatal: Concomitant use of oxytocin may lead to uterine rupture.
Adverse Effects
Side effects of Dinoprostone :
Hypersensitivity reactions, nausea, vomiting, diarrhoea, abdominal pain; flushing, shivering, headache, dizziness; hypertension; convulsions, ECG changes,local tissue irritation, erythema; pyrexia, increased WBC. Uterine contractile abnormalities with or without foetal distress. Dosage >0.5 mg intracervically can cause hypertonic uterine contractions. Intra/extra-amniotic inj: Local infection, vomiting, diarrhoea, pyrexia, transient hypotension.
Potentially Fatal: Sudden CV collapse due to accidental IV absorption and intra-amniotic inj. Uterine rupture, amniotic fluid embolism during labour. Foetal distress and death in rare cases.
Mechanism of Action
Dinoprostone causes induction of uterine muscle contraction during pregnancy. It is both a vasoconstrictor and bronchodilator. The pattern of uterine contraction is similar to that in normal labour at term. It can also stimulate the smooth muscle of the GI tract.
Note
Cerviprime .5mg Cream manufactured by Astra Zeneca. Its generic name is Dinoprostone. Cerviprime is availble in Nepal.
Farmaco Nepal drug index information on Cerviprime Cream is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.