Dinoripe Gel

Dinoprostone
0.5mg
Dr. Reddy's Laboratories.
Pack size
Dispensing mode
Source
Agent
Retail Price 291.40 NPR

Indications

Dinoripe Gel is used for: Cervical priming, induction and augmentation of labour

Adult Dose

Vaginal Cervical Ripening Gel: 2.5 mL (0.5 mg) in cervical canal using syringe and catheter; may repeat after 6 hr, maximum cumulative dose 1.5 mg/24 hr

Child Dose

Renal Dose

Administration

Contra Indications

Hypersensitivity to prostaglandins. Patients in whom oxytocics are generally contraindicated. History of pelvic inflammatory disease; active cardiac, pulmonary, renal or hepatic disease.

Precautions

Raised intraocular pressure. Previous caesarean section; history of asthma, epilepsy, hepatic or renal dysfunction, cardiovascular disease; pregnancy.

Pregnancy-Lactation

Interactions

Potentially Fatal: Concomitant use of oxytocin may lead to uterine rupture.

Adverse Effects

Side effects of Dinoprostone : Hypersensitivity reactions, nausea, vomiting, diarrhoea, abdominal pain; flushing, shivering, headache, dizziness; hypertension; convulsions, ECG changes,local tissue irritation, erythema; pyrexia, increased WBC. Uterine contractile abnormalities with or without foetal distress. Dosage >0.5 mg intracervically can cause hypertonic uterine contractions. Intra/extra-amniotic inj: Local infection, vomiting, diarrhoea, pyrexia, transient hypotension. Potentially Fatal: Sudden CV collapse due to accidental IV absorption and intra-amniotic inj. Uterine rupture, amniotic fluid embolism during labour. Foetal distress and death in rare cases.

Mechanism of Action

Dinoprostone causes induction of uterine muscle contraction during pregnancy. It is both a vasoconstrictor and bronchodilator. The pattern of uterine contraction is similar to that in normal labour at term. It can also stimulate the smooth muscle of the GI tract.

Note

Dinoripe 0.5mg Gel manufactured by Dr. Reddy's Laboratories.. Its generic name is Dinoprostone. Dinoripe is availble in Nepal. Farmaco Nepal drug index information on Dinoripe Gel is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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