DE-Cold Tablet
Chlorpheniramine + Acetaminophen (paracetamol) + Pseudoepedrine
Lomus Pharmaceutical Pvt. Ltd.
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| Retail Price | 3.00 NPR |
Indications
DE-Cold Tablet is used for:
Relief of Nasal Congestion, Cold & Fever
Adult Dose
Relief of Nasal Congestion, Cold & Fever
Adults: Tablet: 2 tablets PO q4-6hr
Syrup: 3 tsf 2-3 times daily
Child Dose
Relief of Nasal Congestion, Cold & Fever
>12 years
Child:
Tablets: 2 tablets PO q4hr
Syrup: 3 tsf 2-3 times daily
Renal Dose
Administration
Contra Indications
Contraindicated in documented hypersensitivity; asthma attacks, narrow-angle glaucoma, symptomatic prostate hypertrophy, bladder-neck obstruction, and stenosing peptic ulcer; known G-6-PD deficiency
Chlorpheniramine may cause significant confusional symptoms; not for administration to < 2 years of age
Use of MAO inhibitor within 14 days
Acetaminophen hepatotoxicity possible in chronic alcoholics following various dose levels; severe or recurrent pain or high or continued fever may indicate a serious illness; contained in many OTC products and combined use with these products may result in toxicity due to cumulative doses exceeding recommended maximum dose
Precautions
Caution in cardiovascular disease, diabetes mellitus, prostatic hypertrophy and increased intraocular pressure when taking pseudoephedrine
Caution in asthma, bladder neck obstruction, cardiovascular disease, COPD, GI obstruction, glaucoma, hepatic impairment, hyperthyroidism, increased intraocular pressure, malnutrition, renal impairment, elderly patients, patients taking CNS depressants or < 6 years of age with chlorpheniramine products
Caution in severe hypovolemia if taking acetaminophen products
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Chlorpheniramine + Acetaminophen (paracetamol) + Pseudoepedrine :
Hypotension,Hypertension,Palpitations,Reflex tachycardia,Severe peripheral and visceral vasoconstriction,Tachycardia,Confusion,Depression,Distress,Dizziness,Euphoria,Excitability,Fatigue,Headache,Insomnia,Irritability,Restlessness,Sedation,Tremors,Dermatologic rash,Anorexia,Agranulocytosis,Anemia blood dyscrasias (neutropenia, pancytopenia, leukopenia),Hemolytic anemia,Thrombocytopenia,Bilirubin and alkaline phosphatase may increase,Thickening of bronchial secretions,Wheezing
Mechanism of Action
Chlorpheniramine blocks muscle responses in histamine and acts as an antagonism of the constrictor effects of histamine on respiratory smooth muscle.
Acetaminophen blocks pain impulse generation peripherally and may inhibit the generation of prostaglandin in the CNS. Reduces fever by inhibiting the hypothalamic heat-regulating center.
Pseudoephedrine stimulates the alpha-adrenergic receptors causing bronchodilation and vasoconstriction.
Note
DE-Cold Tablet manufactured by Lomus Pharmaceutical Pvt. Ltd.. Its generic name is Chlorpheniramine + Acetaminophen (paracetamol) + Pseudoepedrine. DE-Cold is availble in Nepal.
Farmaco Nepal drug index information on DE-Cold Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.