Depslo Forte Tablet
Diazepam + Imipramine
(5 mg)+(25 mg)
Intas Pharmaceuticals Ltd.
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Indications
Depslo Forte Tablet is used for:
Used in the treatment of depression
Adult Dose
Oral
Depression
Adult: One 5/25mg tablet 2-3 times daily, dose may gradually increase.
Child Dose
Renal Dose
Administration
May be taken with or without food
Contra Indications
It is not recommended during pregnancy or breastfeeding.
Precautions
May cause excessive drowsiness with alcohol.
May impair alertness or cause drowsiness or blurred vision, and this may affect ability to drive.
Used with caution in patients with kidney & liver disease.
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Diazepam + Imipramine :
Constipation
Difficulty in urination
Weight gain
Confusion
Orthostatic hypotension
Tiredness
Blurred vision
Dryness in mouth
Increased heart rate
Uncoordinated body movement
Depression
Memory impairement
Mechanism of Action
Imipramine is believed to increase the synaptic concentration of serotonin and/or norepinephrine in the CNS by inhibition of their reuptake by the presynaptic neuronal membrane. However, additional receptor effects have been found including desensitisation of adenyl cyclase, down regulation of β-adrenergic receptors, and down regulation of serotonin receptors.
Diazepam is a long-acting benzodiazepine w/ anticonvulsant, anxiolytic, sedative, muscle relaxant and amnestic properties. It increases neuronal membrane permeability to Cl ions by binding to stereospecific benzodiazepine receptors on the postsynaptic GABA neuron w/in the CNS and enhancing the GABA inhibitory effects resulting in hyperpolarisation and stabilisation.
Note
Depslo Forte (5 mg)+(25 mg) Tablet manufactured by Intas Pharmaceuticals Ltd.. Its generic name is Diazepam + Imipramine. Depslo Forte is availble in Nepal.
Farmaco Nepal drug index information on Depslo Forte Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.