IMID PLUS Tablet

Diazepam + Imipramine
2mg + 25mg
Nepal Pharmaceuticals Pvt. Ltd.
Pack size
Dispensing mode
Source
Agent
Retail Price 1.20 NPR

Indications

IMID PLUS Tablet is used for: Used in the treatment of depression

Adult Dose

Oral Depression Adult: One 5/25mg tablet 2-3 times daily, dose may gradually increase.

Child Dose

Renal Dose

Administration

May be taken with or without food

Contra Indications

It is not recommended during pregnancy or breastfeeding.

Precautions

May cause excessive drowsiness with alcohol. May impair alertness or cause drowsiness or blurred vision, and this may affect ability to drive. Used with caution in patients with kidney & liver disease.

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Diazepam + Imipramine : Constipation Difficulty in urination Weight gain Confusion Orthostatic hypotension Tiredness Blurred vision Dryness in mouth Increased heart rate Uncoordinated body movement Depression Memory impairement

Mechanism of Action

Imipramine is believed to increase the synaptic concentration of serotonin and/or norepinephrine in the CNS by inhibition of their reuptake by the presynaptic neuronal membrane. However, additional receptor effects have been found including desensitisation of adenyl cyclase, down regulation of β-adrenergic receptors, and down regulation of serotonin receptors. Diazepam is a long-acting benzodiazepine w/ anticonvulsant, anxiolytic, sedative, muscle relaxant and amnestic properties. It increases neuronal membrane permeability to Cl ions by binding to stereospecific benzodiazepine receptors on the postsynaptic GABA neuron w/in the CNS and enhancing the GABA inhibitory effects resulting in hyperpolarisation and stabilisation.

Note

IMID PLUS 2mg + 25mg Tablet manufactured by Nepal Pharmaceuticals Pvt. Ltd.. Its generic name is Diazepam + Imipramine. IMID PLUS is availble in Nepal. Farmaco Nepal drug index information on IMID PLUS Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Diazepam + Imipramine :