Dextran 40 Injection
Dextran 40
40mg/ml
Micro Labs Ltd.
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Indications
Dextran 40 Injection is used for:
Hypovolaemic shock, Thromboembolic disorders, Prophylaxis of postoperative thromboembolic disorders
Adult Dose
Intravenous
Hypovolaemic shock
Adult: As dextran 40: Initially, 10 ml/kg given by rapid infusion as a 10% solution in sodium chloride 0.9% or glucose 5%. Doses may be given daily for up to 5 days.
Thromboembolic disorders
Adult: As dextran 40: Initially, 500 ml of a 10% solution in sodium chloride 0.9% or glucose 5% infused over 4-6 hr, followed by 500 ml infused over 4-6 hr on the next and subsequent alternate days for not more than 10 days.
Prophylaxis of postoperative thromboembolic disorders
Adult: As dextran 40: 500 ml of a 10% solution in sodium chloride 0.9% or glucose 5% infused over 4-6 hr during or at the end of the surgery. Dose may be repeated the following day and treatment may be continued on alternate days for up to 10 days in high-risk patient.
Child Dose
Intravenous
Thromboembolic disorders
Child: As dextran 40: Up to 5 ml/kg in infants and 10 ml/kg in children.
Prophylaxis of postoperative thromboembolic disorders
Child: As dextran 40: Up to 10 ml/kg in children.
Renal Dose
Administration
Contra Indications
Hypersensitivity. Severe renal disease with oliguria or anuria. Marked cardiac decompensation. Pregnancy.
Precautions
Lactation.
Pregnancy-Lactation
Interactions
Enzyme inducers e.g. phenytoin or carbamazepine and enzyme inhibitors e.g. cimetidine.
Adverse Effects
Side effects of Dextran 40 :
GI disturbances; headache, dizziness; allergic reactions; raised liver enzyme values; alopecia; bone marrow suppression.
Mechanism of Action
Dextrans produce expansion of plasma volume. It also reduces blood viscosity and inhibits sludging or aggregation of red blood cells.
Note
Dextran 40 40mg/ml Injection manufactured by Micro Labs Ltd.. Its generic name is Dextran 40. Dextran 40 is availble in Nepal.
Farmaco Nepal drug index information on Dextran 40 Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.