Rallidex 10% Solution
Dextran 40
Shreya Life Sciences Pvt Ltd
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Indications
Rallidex 10% Solution is used for:
Hypovolaemic shock, Thromboembolic disorders, Prophylaxis of postoperative thromboembolic disorders
Adult Dose
Intravenous
Hypovolaemic shock
Adult: As dextran 40: Initially, 10 ml/kg given by rapid infusion as a 10% solution in sodium chloride 0.9% or glucose 5%. Doses may be given daily for up to 5 days.
Thromboembolic disorders
Adult: As dextran 40: Initially, 500 ml of a 10% solution in sodium chloride 0.9% or glucose 5% infused over 4-6 hr, followed by 500 ml infused over 4-6 hr on the next and subsequent alternate days for not more than 10 days.
Prophylaxis of postoperative thromboembolic disorders
Adult: As dextran 40: 500 ml of a 10% solution in sodium chloride 0.9% or glucose 5% infused over 4-6 hr during or at the end of the surgery. Dose may be repeated the following day and treatment may be continued on alternate days for up to 10 days in high-risk patient.
Child Dose
Intravenous
Thromboembolic disorders
Child: As dextran 40: Up to 5 ml/kg in infants and 10 ml/kg in children.
Prophylaxis of postoperative thromboembolic disorders
Child: As dextran 40: Up to 10 ml/kg in children.
Renal Dose
Administration
Contra Indications
Hypersensitivity. Severe renal disease with oliguria or anuria. Marked cardiac decompensation. Pregnancy.
Precautions
Lactation.
Pregnancy-Lactation
Interactions
Enzyme inducers e.g. phenytoin or carbamazepine and enzyme inhibitors e.g. cimetidine.
Adverse Effects
Side effects of Dextran 40 :
GI disturbances; headache, dizziness; allergic reactions; raised liver enzyme values; alopecia; bone marrow suppression.
Mechanism of Action
Dextrans produce expansion of plasma volume. It also reduces blood viscosity and inhibits sludging or aggregation of red blood cells.
Note
Rallidex 10% Solution manufactured by Shreya Life Sciences Pvt Ltd. Its generic name is Dextran 40. Rallidex 10% is availble in Nepal.
Farmaco Nepal drug index information on Rallidex 10% Solution is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.