Available as:
Indications
Doxacard 4 Tablet is used for:
Hypertension, Benign Prostatic Hyperplasia
Adult Dose
Oral
Hypertension
Adult: Initially, 1 mg at bedtime, may be doubled at 1-2 wk intervals according to response. Maintenance: Up to 4 mg once daily. Max: 16 mg/day.
Extended-release: Initially, 4 mg once daily, may increase to max 8 mg once daily after 4 wk.
Benign prostatic hyperplasia
Adult: Initially, 1 mg at bedtime, may be doubled at 1-2 wk intervals according to response. Maintenance: 2-4 mg/day. Max: 8 mg/day.
Extended-release: Initially, 4 mg once daily, may increase to max 8 mg once daily after 4 wk.
Hepatic impairment: Use with caution in mild-to-moderate hepatic dysfunction; do not use in severe impairment
Child Dose
Renal Dose
Administration
May be taken with or without food. Give first dose and increase at bedtime to avoid syncope
Contra Indications
Patient w/ history of orthostatic hypotension; benign prostatic hyperplasia and concomitant congestion of the upper urinary tract, chronic urinary tract infection or bladder stones; monotherapy in patients w/ either overflow bladder or anuria w/ or w/o progressive renal insufficiency.
Precautions
Prostatic carcinoma should be ruled out before starting therapy. Hepatic impairment. Pregnancy and lactation. Patient Counselling May impair ability to drive and operate machinery. Monitoring Parameters Monitor BP and renal function.
Lactation: Unknown whether drug is excreted in milk; use with caution
Pregnancy-Lactation
Interactions
Concomitant admin w/ phosphodiesterase type 5 (PDE-5) inhibitors (e.g. sildenafil) may lead to symptomatic hypotension. Potentiates the BP lowering activity of other α-blockers and other antihypertensives.
Adverse Effects
Side effects of Doxazosin :
>10%
Dizziness (5-19%),Fatigue (8-12%),Headache (6-10%)
1-10%
Vertigo (7%),Upper respiratory tract infection (URTI) (5%),Edema (3-4%),Rhinitis (3%),Dyspnea (1-3%),Abdominal pain (2%),Hypotension (1-2%),Nausea (1-2%),Orthostatic hypotension (dose related) (0.3-2%),Anxiety (1%),Palpitations (1%)
Mechanism of Action
Hypertension: Blocks postsynaptic alpha1 receptors; alpha blockade causes arterial, arteriolar, and venous dilation; decreases total peripheral resistance and blood pressure
Benign prostatic hyperplasia (BPH): Blocks alpha1 receptors in prostatic stromal and bladder tissues; reduces sympathetic tone-induced urethral stricture responsible for BPH symptoms
Note
Doxacard 4 4mg Tablet manufactured by Cipla Ltd.. Its generic name is Doxazosin. Doxacard 4 is availble in Nepal.
Farmaco Nepal drug index information on Doxacard 4 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.