Duracard 2 Tablet

Doxazosin
2mg
Sun Pharmaceutical Industries Ltd.
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Indications

Duracard 2 Tablet is used for: Hypertension, Benign Prostatic Hyperplasia

Adult Dose

Oral Hypertension Adult: Initially, 1 mg at bedtime, may be doubled at 1-2 wk intervals according to response. Maintenance: Up to 4 mg once daily. Max: 16 mg/day. Extended-release: Initially, 4 mg once daily, may increase to max 8 mg once daily after 4 wk. Benign prostatic hyperplasia Adult: Initially, 1 mg at bedtime, may be doubled at 1-2 wk intervals according to response. Maintenance: 2-4 mg/day. Max: 8 mg/day. Extended-release: Initially, 4 mg once daily, may increase to max 8 mg once daily after 4 wk. Hepatic impairment: Use with caution in mild-to-moderate hepatic dysfunction; do not use in severe impairment

Child Dose

Renal Dose

Administration

May be taken with or without food. Give first dose and increase at bedtime to avoid syncope

Contra Indications

Patient w/ history of orthostatic hypotension; benign prostatic hyperplasia and concomitant congestion of the upper urinary tract, chronic urinary tract infection or bladder stones; monotherapy in patients w/ either overflow bladder or anuria w/ or w/o progressive renal insufficiency.

Precautions

Prostatic carcinoma should be ruled out before starting therapy. Hepatic impairment. Pregnancy and lactation. Patient Counselling May impair ability to drive and operate machinery. Monitoring Parameters Monitor BP and renal function. Lactation: Unknown whether drug is excreted in milk; use with caution

Pregnancy-Lactation

Interactions

Concomitant admin w/ phosphodiesterase type 5 (PDE-5) inhibitors (e.g. sildenafil) may lead to symptomatic hypotension. Potentiates the BP lowering activity of other α-blockers and other antihypertensives.

Adverse Effects

Side effects of Doxazosin : >10% Dizziness (5-19%),Fatigue (8-12%),Headache (6-10%) 1-10% Vertigo (7%),Upper respiratory tract infection (URTI) (5%),Edema (3-4%),Rhinitis (3%),Dyspnea (1-3%),Abdominal pain (2%),Hypotension (1-2%),Nausea (1-2%),Orthostatic hypotension (dose related) (0.3-2%),Anxiety (1%),Palpitations (1%)

Mechanism of Action

Hypertension: Blocks postsynaptic alpha1 receptors; alpha blockade causes arterial, arteriolar, and venous dilation; decreases total peripheral resistance and blood pressure Benign prostatic hyperplasia (BPH): Blocks alpha1 receptors in prostatic stromal and bladder tissues; reduces sympathetic tone-induced urethral stricture responsible for BPH symptoms

Note

Duracard 2 2mg Tablet manufactured by Sun Pharmaceutical Industries Ltd.. Its generic name is Doxazosin. Duracard 2 is availble in Nepal. Farmaco Nepal drug index information on Duracard 2 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Doxazosin :