Fadine Tablet

Famotidine
40mg
Aristo Pharmaceuticals Ltd.
Pack size 1
Dispensing mode
Source
Agent
Retail Price 0.65 NPR

Available as:

Indications

Fadine Tablet is used for: Heartburn, Peptic ulcer, Dyspepsia, Urticaria, Zollinger-Ellison syndrome, Gastroesophageal reflux disease (GERD)

Adult Dose

Oral Benign gastric and duodenal ulceration Adult: 40 mg daily at bedtime for 4-8 wk or 20 mg bid. Maintenance: 20 mg at bedtime to prevent recurrence of duodenal ulceration. Gastro-oesophageal reflux disease Adult: 20 mg bid for 6-12 wk or up to 40 mg bid if there is oesophageal ulceration. Maintenance: 20 mg bid to prevent recurrence. Zollinger-Ellison syndrome Adult: Initially, 20 mg 6 hrly, up to 800 mg/day if necessary. Non-ulcer dyspepsia ; Heartburn Adult: 10-20 mg once or bid.

Child Dose

Peptic Ulcer 1-16 years: 0.5 mg/kg PO at bedtime; not to exceed 40 mg/day Gastroesophageal Reflux Disease <3 months: 0.5 mg/kg PO once daily for up to 8 weeks 3-12 months: 0.5 mg/kg PO q12hr for up to 8 weeks 1-16 years: 1 mg/kg/day PO divided q12hr; individual dose not to exceed 40 mg Heartburn <12 years: Not established >12 years: 10-20 mg q12 hr; may take 15-60 min before eating foods that could cause heartburn

Renal Dose

Renal impairment: CrCl (ml/min) Dosage Recommendation <50 Reduce the dose by half or increase dosing interval to 36-48 hr.

Administration

May be taken with or without food. Reconstitution: For IV inj: Famotidine 20 mg is diluted to a total of 5 or 10 mL w/ NaCl 0.9% inj or dextrose 5% or 10% inj, lactated Ringer's, water for inj soln to provide a soln containing approx 4 or 2 mg/mL, respectively. For intermittent IV infusion: Famotidine 20 mg is added to dextrose 5% inj 100 mL or NaCl 0.9% inj, lactated Ringer's soln, water for inj soln to provide a soln containing approximately 0.2 mg/mL. IV Administration Infuse at rate no faster than 10 mg/min

Contra Indications

Hypersensitivity.

Precautions

Impaired renal function. Long term treatment should be avoided. Lactation: Drug enters breast milk; use not recommended

Pregnancy-Lactation

Interactions

Antacids slightly decrease the bioavailability of famotidine. May reduce serum concentration of ketoconazole and itraconazole.

Adverse Effects

Side effects of Famotidine : 1-10% Headache (4.7%),Diarrhea (1.7%),Dizziness (1.3%),Constipation (1.2%) Frequency Not Defined Body as a whole: Fever, asthenia, fatigue Cardiovascular: Arrhythmia, AV block, palpitation; prolonged QT interval in patients with impaired renal function, has been reported very rarely Gastrointestinal: Cholestatic jaundice, hepatitis, liver enzyme abnormalities, vomiting, nausea, abdominal discomfort, anorexia, dry mouth Hematologic: Rare cases of agranulocytosis, pancytopenia, leukopenia, thrombocytopenia Hypersensitivity: Anaphylaxis, angioedema, orbital or facial edema, urticaria, rash, conjunctival injection Musculoskeletal: Rhabdomyolysis, musculoskeletal pain including muscle cramps, arthralgia Nervous system/psychiatric: Grand mal seizure; psychic disturbances, which were reversible in cases for which follow-up was obtained, including hallucinations, confusion, agitation, depression, anxiety, decreased libido; paresthesia; insomnia; somnolence; convulsions, in patients with impaired renal function, have been reported very rarely Respiratory: Bronchospasm, interstitial pneumonia Skin: Toxic epidermal necrolysis/Stevens-Johnson syndrome (very rare), alopecia, acne, pruritus, dry skin, flushing Special senses: Tinnitus, taste disorder Rare cases of impotence and rare cases of gynecomastia

Mechanism of Action

Famotidine competitively blocks histamine at H2-receptors thus reducing basal, nocturnal and stimulated gastric acid secretion. Pepsin secretion is reduced resulting in decreased peptic activity.

Note

Fadine 40mg Tablet manufactured by Aristo Pharmaceuticals Ltd.. Its generic name is Famotidine. Fadine is availble in Nepal. Farmaco Nepal drug index information on Fadine Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Famotidine :