FAM O Tablet
Famotidine
40mg
Omnica Laboratories Pvt. Ltd..
| Pack size | 1 |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 2.00 NPR |
Available as:
Indications
FAM O Tablet is used for:
Heartburn, Peptic ulcer, Dyspepsia, Urticaria, Zollinger-Ellison syndrome, Gastroesophageal reflux disease (GERD)
Adult Dose
Oral
Benign gastric and duodenal ulceration
Adult: 40 mg daily at bedtime for 4-8 wk or 20 mg bid. Maintenance: 20 mg at bedtime to prevent recurrence of duodenal ulceration.
Gastro-oesophageal reflux disease
Adult: 20 mg bid for 6-12 wk or up to 40 mg bid if there is oesophageal ulceration. Maintenance: 20 mg bid to prevent recurrence.
Zollinger-Ellison syndrome
Adult: Initially, 20 mg 6 hrly, up to 800 mg/day if necessary.
Non-ulcer dyspepsia ; Heartburn
Adult: 10-20 mg once or bid.
Child Dose
Peptic Ulcer
1-16 years: 0.5 mg/kg PO at bedtime; not to exceed 40 mg/day
Gastroesophageal Reflux Disease
<3 months: 0.5 mg/kg PO once daily for up to 8 weeks
3-12 months: 0.5 mg/kg PO q12hr for up to 8 weeks
1-16 years: 1 mg/kg/day PO divided q12hr; individual dose not to exceed 40 mg
Heartburn
<12 years: Not established
>12 years: 10-20 mg q12 hr; may take 15-60 min before eating foods that could cause heartburn
Renal Dose
Renal impairment:
CrCl (ml/min) Dosage Recommendation
<50 Reduce the dose by half or increase dosing interval to 36-48 hr.
Administration
May be taken with or without food.
Reconstitution: For IV inj: Famotidine 20 mg is diluted to a total of 5 or 10 mL w/ NaCl 0.9% inj or dextrose 5% or 10% inj, lactated Ringer's, water for inj soln to provide a soln containing approx 4 or 2 mg/mL, respectively.
For intermittent IV infusion: Famotidine 20 mg is added to dextrose 5% inj 100 mL or NaCl 0.9% inj, lactated Ringer's soln, water for inj soln to provide a soln containing approximately 0.2 mg/mL.
IV Administration
Infuse at rate no faster than 10 mg/min
Contra Indications
Hypersensitivity.
Precautions
Impaired renal function. Long term treatment should be avoided.
Lactation: Drug enters breast milk; use not recommended
Pregnancy-Lactation
Interactions
Antacids slightly decrease the bioavailability of famotidine. May reduce serum concentration of ketoconazole and itraconazole.
Adverse Effects
Side effects of Famotidine :
1-10%
Headache (4.7%),Diarrhea (1.7%),Dizziness (1.3%),Constipation (1.2%)
Frequency Not Defined
Body as a whole: Fever, asthenia, fatigue
Cardiovascular: Arrhythmia, AV block, palpitation; prolonged QT interval in patients with impaired renal function, has been reported very rarely
Gastrointestinal: Cholestatic jaundice, hepatitis, liver enzyme abnormalities, vomiting, nausea, abdominal discomfort, anorexia, dry mouth
Hematologic: Rare cases of agranulocytosis, pancytopenia, leukopenia, thrombocytopenia
Hypersensitivity: Anaphylaxis, angioedema, orbital or facial edema, urticaria, rash, conjunctival injection
Musculoskeletal: Rhabdomyolysis, musculoskeletal pain including muscle cramps, arthralgia
Nervous system/psychiatric: Grand mal seizure; psychic disturbances, which were reversible in cases for which follow-up was obtained, including hallucinations, confusion, agitation, depression, anxiety, decreased libido; paresthesia; insomnia; somnolence; convulsions, in patients with impaired renal function, have been reported very rarely
Respiratory: Bronchospasm, interstitial pneumonia
Skin: Toxic epidermal necrolysis/Stevens-Johnson syndrome (very rare), alopecia, acne, pruritus, dry skin, flushing
Special senses: Tinnitus, taste disorder
Rare cases of impotence and rare cases of gynecomastia
Mechanism of Action
Famotidine competitively blocks histamine at H2-receptors thus reducing basal, nocturnal and stimulated gastric acid secretion. Pepsin secretion is reduced resulting in decreased peptic activity.
Note
FAM O 40mg Tablet manufactured by Omnica Laboratories Pvt. Ltd... Its generic name is Famotidine. FAM O is availble in Nepal.
Farmaco Nepal drug index information on FAM O Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.