Finorate Tablet
Fenofibrate
160mg
Alive Pharmaceutical. Pvt. Ltd.
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| Retail Price | 12.00 NPR |
Available as:
Indications
Finorate Tablet is used for:
Hyperlipidemia,Hypercholesterolaemia,Hypertriglyceridaemia
Adult Dose
Oral
Hypercholesterolemia, Mixed dyslipidemia, Hypertriglyceridemia
Tablet: 40-160mg once daily.
Capsule: 200mg once daily.
Hepatic impairment: Contraindicated.
Child Dose
Safety and efficacy not established
Renal Dose
Renal impairment
Mild-Moderate: Initial: lower dose
Severe: contraindicated
Administration
Should be taken with food.
Contra Indications
Hypersensitivity; severe hepatic and renal impairment. Unexplained persistent liver function abnormality and primary biliary cirrhosis; preexisting gall bladder disease. Pregnancy, lactation.
Precautions
Renal or hepatic impairment. Monitor LFTs and blood counts regularly. Increased risk of cholelithiasis, pancreatitis, skeletal muscle effects. Withdraw treatment if no adequate response after 2 mth of treatment at max recommended dose.
Lactation: Unknown if excreted in breast milk; not recommended
Pregnancy-Lactation
Interactions
Decreased absorption w/ bile acid sequestrants (e.g. colestyramine). May increase risk of ciclosporin-induced nephrotoxicity. Increased risk of muscle toxicity w/ HMG-CoA reductase inhibitors (e.g. simvastatin). May increase risk of bleeding w/ oral anticoagulants.
Adverse Effects
Side effects of Fenofibrate :
1-10%
Abdominal pain (4.6%),Back pain (3.4%),Increased AST (3.4%),Headache (3.2%),Increased ALT (3%),Increased CPK (3%),Nausea (2.3%),Constipation (2.1%)
Potentially Fatal: Hepatitis, cholecystitis.
Mechanism of Action
Fenofibrate, a fibric acid derivative, lowers plasma triglyceride by activating lipoprotein lipase thus increasing catabolism of VLDL w/ consequent increase in HDL levels.
Note
Finorate 160mg Tablet manufactured by Alive Pharmaceutical. Pvt. Ltd.. Its generic name is Fenofibrate. Finorate is availble in Nepal.
Farmaco Nepal drug index information on Finorate Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.