Gmectin Tablet
Ivermectin
6mg
G.D. Laboratories Pvt. Ltd.
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Indications
Gmectin Tablet is used for:
Ascariasis, Strongyloidiasis, Filariasis, Scabies, Onchocerciasis, Gnathostomiasis
Adult Dose
Strongyloidiasis of the Intestinal Tract
15-24 kg: 3 mg PO once
25-35 kg: 6 mg PO once
36-50 kg: 9 mg PO once
51-65 kg: 12 mg PO once
66-79 kg: 15 mg PO once
>80 kg: 200 mcg/kg PO once
River Blindness (Onchocerciasis)
15-25 kg: 3 mg PO; may repeat in 3-12 mo
26-44 kg: 6 mg PO; may repeat in 3-12 mo
45-64 kg: 9 mg PO; may repeat in 3-12 mo
65-84 kg: 12 mg PO; may repeat in 3-12 mo
>85 kg: 150 mcg/kg PO; may repeat in 3-12 mo
Scabies Due to Sarcoptes Scabiel
Immunocompromised patients: 200 mcg/kg as single dose; may repeat in 14 days if necessary
Gnathostoma Spinigerum
Gnathostomiasis: 200 mcg/kg as single dose
Child Dose
River Blindness (Onchocerciasis)
<15 kg: Safety and efficacy not established
15-25 kg: 3 mg PO; may repeat in 3-12 mo
26-44 kg: 6 mg PO; may repeat in 3-12 mo
45-64 kg: 9 mg PO; may repeat in 3-12 mo
65-84 kg: 12 mg PO; may repeat in 3-12 mo
>85 kg: 150 mcg/kg PO; may repeat in 3-12 mo
Strongyloidiasis of the Intestinal Tract
<15 kg: Safety and efficacy not established
15-24 kg: 3 mg PO once
25-35 kg: 6 mg PO once
36-50 kg: 9 mg PO once
51-65 kg: 12 mg PO once
66-79 kg: 15 mg PO once
>80 kg: 200 mcg/kg PO once
Renal Dose
Administration
Should be taken on an empty stomach.
Contra Indications
Hypersensitivity. Pregnancy and lactation. Childn <15 kg body weight.
Precautions
Concurrent Loa loa infection, impaired blood-brain barrier function due to infection.
Lactation: Enters breast milk (AAP Committee states compatible with nursing)
Pregnancy-Lactation
Interactions
Bioavailability may be increased by alcohol, levamisole.
Adverse Effects
Side effects of Ivermectin :
Diarrhoea, nausea, vomiting, dizziness, pruritus, urticaria, rash, arthralgia, fever, myalgia, asthenia, postural hypotension, tachycardia, oedema, lymphadenopathy, sore throat, cough, headache, somnolence, transient eosinophilia, raised liver enzyme values.
Mechanism of Action
Ivermectin selectively binds and with high affinity to glutamate-gated chloride ion channels, which occur in invertebrate nerve and muscle cells leading to an increase in the permeability of cell membranes to chloride ions with hyperpolarization of the nerve or muscle cell and, ultimately, death of the parasite.
Note
Gmectin 6mg Tablet manufactured by G.D. Laboratories Pvt. Ltd.. Its generic name is Ivermectin. Gmectin is availble in Nepal.
Farmaco Nepal drug index information on Gmectin Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.