I-Pill 1.5 Tablet
Levonorgestrel
1.5mg
Cipla Ltd.
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Available as:
Indications
I-Pill 1.5 Tablet is used for:
Contraception , Emergency contraception , Menopausal hormone replacement therapy , Menorrhagia,
Adult Dose
Oral
Emergency contraception
Adult: 1.5 mg as soon as possible or within 72 hr of coitus.
Alternatively, 750 mcg as soon as possible or within 72 hr of coitus followed by a 2nd dose 12 hr later.
Most effective if taken as soon as possible after unprotected intercourse
Menopausal hormone replacement therapy
Adult: As progestogenic component: 75-250 mcg for 10-12 days of a 28-day cycle.
Contraception
Adult: Monotherapy: 30 or 37.5 mcg daily.
Child Dose
Renal Dose
Administration
May be taken with or without food.
Contra Indications
Pregnancy, undiagnosed vaginal bleeding, severe arterial disease; liver adenoma, porphyria; after recent evacuation of hydatidiform mole; history of breast cancer; hepatic impairment.
Precautions
Sex-steroid dependent cancer, past ectopic pregnancy, malabsorption syndromes, functional ovarian cysts, active liver disease, recurrent cholestatic jaundice, history of jaundice in pregnancy, CV or renal impairment, DM, asthma, epilepsy, migraine, conditions aggravated by fluid retention, depression and thromboembolism (high doses); lactation.
Pregnancy-Lactation
Interactions
Reduced efficacy with enzyme-inducing drugs; aminoglutethimide. May inhibit ciclosporin metabolism.
Adverse Effects
Side effects of Levonorgestrel :
>10%
Headache (12%),Acne (15%),Ovarian cysts (13%),Enlarged follicles (12%),Amenorrhea (1-12%),Abdominal pain (12%),Uterine/vaginal bleeding alterations (52%),Intermenstrual bleeding/spotting (23%),Vulvovaginitis (20%),Ectopic pregnancy (≤50%)
1-10%
Depression (4%),Migraine (2%),Alopecia (1%),Dysmenorrhea (9%),Menorrhagia (6%),Breast tenderness (3-9%),Pelvic pain (6%),Leukorrhea (5%),Vaginal discharge (4%),Pelvic infection (1%)
<1%
Angioedema,Cervical perforation,Failed insertion,Sepsis,Uterine bleeding,Device breakage
Potentially Fatal: Thrombocytopenia, stroke.
Mechanism of Action
Levonorgestrel, a nortestosterone derivative, is an active isomer of norgestrel. It is a potent inhibitor of ovulation and has androgenic activity.
Note
I-Pill 1.5 1.5mg Tablet manufactured by Cipla Ltd.. Its generic name is Levonorgestrel. I-Pill 1.5 is availble in Nepal.
Farmaco Nepal drug index information on I-Pill 1.5 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.