Neozeet Syrup
Dextromethorphan + Promethazine
Alembic Pharmaceuticals Ltd.
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| Retail Price | 86.23 NPR |
Indications
Neozeet Syrup is used for:
Temporary relief of cough and upper respiratory tract symptoms associated with allergy or the common cold
Adult Dose
Cough
Adult
Temporary relief of cough and upper respiratory tract symptoms associated with allergy or the common cold
5 mL (6.25 mg/15 mg) PO q4-6hr PRN
Maximum: 30 mL/24 hr
Child Dose
Cough
<2 years: Contraindicated
2-6 years: 1.25-2.5 mL PO q4-6hr, up to 12.5 mg/30 mg (10 mL) in 24 hr
6-12 years: 2.5-5 mL PO 4-6hr, up to 25 mg/60 mg (20 mL) in 24 hr
>12 years: 6.25 mg/15 mg (5 mL) PO q4-6hr PRN, not to exceed 30 mL/24 hr
Renal Dose
Administration
Contra Indications
Promethazine
Hypersensitivity
Newborn/premature infants, <2 years (risk of potentially fatal respiratory depression)
Subcutaneous or intra-arterial administration
BPH
Narrow angle glaucoma
Pyloroduodenal obstruction, stenosing peptic ulcer, bladder neck obstruction
Severe CNS depression
Coma, Severe respiratory depression
Dextromethorphan
Concurrent nonselective MAO inhibitors: serotonin syndrome
Precautions
Do not use in patients <2 years of age because of potential for fatal respiratory depression; administer with caution to children >2 years of age
Promethazine
CVD, asthma, hepatic impairment, peptic ulcer, respiratory impairment
Anaphylaxis in susceptible individuals
May impair ability to drive or perform hazardous tasks
Monitor closely in patients with
-Cardiovascular disease
- Hepatic impairment
- Reye syndrome
- History of sleep apnea
Depresses hypothalamic thermoregulatory mechanism; exposure to extreme temperatures may cause hypo- or hyperthermia
Antiemetic effect may obscure toxicity of chemotherapeutic drugs
Dextromethorphan
Phenylketonuria: Contains aspartame
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Dextromethorphan + Promethazine :
Frequency Not Defined
Promethazine
Anticholinergic effects: dry mouth, blurred vision
Tachy/bradycardia
Confusion, disorientation, EPS, sedation
Photosensitivity
Agranulocytosis, leukopenia
Obstructive jaundice
Dextromethorphan
Dizziness
Drowsiness
Sedation
Constipation
Nausea
Vomiting
Blurred vision
Nystagmus
Mechanism of Action
Promethazine: Antidopaminergic effect due to blocking mesolimbic dopamine receptors and alpha-adrenergic receptors in the brain; antihistaminic effect due to blocking H1-receptors
Dextromethorphan: Acts on cough center in medulla; derivative of levorphanol
Note
Neozeet Syrup manufactured by Alembic Pharmaceuticals Ltd.. Its generic name is Dextromethorphan + Promethazine. Neozeet is availble in Nepal.
Farmaco Nepal drug index information on Neozeet Syrup is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.