Synohist Syrup

Dextromethorphan + Promethazine
7.5mg + 2.5mg
Siddhartha Pharmaceuticals Pvt. Ltd.
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Indications

Synohist Syrup is used for: Temporary relief of cough and upper respiratory tract symptoms associated with allergy or the common cold

Adult Dose

Cough Adult Temporary relief of cough and upper respiratory tract symptoms associated with allergy or the common cold 5 mL (6.25 mg/15 mg) PO q4-6hr PRN Maximum: 30 mL/24 hr

Child Dose

Cough <2 years: Contraindicated 2-6 years: 1.25-2.5 mL PO q4-6hr, up to 12.5 mg/30 mg (10 mL) in 24 hr 6-12 years: 2.5-5 mL PO 4-6hr, up to 25 mg/60 mg (20 mL) in 24 hr >12 years: 6.25 mg/15 mg (5 mL) PO q4-6hr PRN, not to exceed 30 mL/24 hr

Renal Dose

Administration

Contra Indications

Promethazine Hypersensitivity Newborn/premature infants, <2 years (risk of potentially fatal respiratory depression) Subcutaneous or intra-arterial administration BPH Narrow angle glaucoma Pyloroduodenal obstruction, stenosing peptic ulcer, bladder neck obstruction Severe CNS depression Coma, Severe respiratory depression Dextromethorphan Concurrent nonselective MAO inhibitors: serotonin syndrome

Precautions

Do not use in patients <2 years of age because of potential for fatal respiratory depression; administer with caution to children >2 years of age Promethazine CVD, asthma, hepatic impairment, peptic ulcer, respiratory impairment Anaphylaxis in susceptible individuals May impair ability to drive or perform hazardous tasks Monitor closely in patients with -Cardiovascular disease - Hepatic impairment - Reye syndrome - History of sleep apnea Depresses hypothalamic thermoregulatory mechanism; exposure to extreme temperatures may cause hypo- or hyperthermia Antiemetic effect may obscure toxicity of chemotherapeutic drugs Dextromethorphan Phenylketonuria: Contains aspartame

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Dextromethorphan + Promethazine : Frequency Not Defined Promethazine Anticholinergic effects: dry mouth, blurred vision Tachy/bradycardia Confusion, disorientation, EPS, sedation Photosensitivity Agranulocytosis, leukopenia Obstructive jaundice Dextromethorphan Dizziness Drowsiness Sedation Constipation Nausea Vomiting Blurred vision Nystagmus

Mechanism of Action

Promethazine: Antidopaminergic effect due to blocking mesolimbic dopamine receptors and alpha-adrenergic receptors in the brain; antihistaminic effect due to blocking H1-receptors Dextromethorphan: Acts on cough center in medulla; derivative of levorphanol

Note

Synohist 7.5mg + 2.5mg Syrup manufactured by Siddhartha Pharmaceuticals Pvt. Ltd.. Its generic name is Dextromethorphan + Promethazine. Synohist is availble in Nepal. Farmaco Nepal drug index information on Synohist Syrup is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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