PRU Syrup
Hydroxyzine Hydrochloride
100ML
Yash Pharma Laboratories Pvt. Ltd.
| Pack size | 1's |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 79.20 NPR |
Available as:
Indications
PRU Syrup is used for:
Pruritus, Allergic conditions, Generalized anxiety disorder, Psychoneurosis, Chronic urticaria, Atopic or contact dermatoses, Pre- or post-operative sedation
Adult Dose
Oral
Short-term management of anxiety
Adult: 50-100 mg 4 times daily.
Pruritus in acute and chronic urticaria and dermatosis
Adult: Initially, 25 mg at night increased if required up to 25 mg 3-4 times daily.
Adjunct to pre- or post-operative sedation
Adult: 50-100 mg.
Hepatic impairment: Reduce total daily dose by 33%.
Child Dose
Oral
Pruritus in acute and chronic urticaria and dermatosis
Child: 6 mth to 6 yr Initially, 5-15 mg/day, increased to 50 mg/day in divided doses;
>6 yr Initially, 15-25 mg/day, increased up to 50-100 mg/day in divided doses.
Adjunct to pre- or post-operative sedation
Child: 600 mcg/kg.
Hepatic impairment: Reduce total daily dose by 33%.
Renal Dose
Renal Impairment
>50 mL/min: Dose adjustment not necessary
<50 mL/min: Administer 50% normal dose
Administration
May be taken with or without food.
Contra Indications
Porphyria, neonates, pregnancy, lactation.
Precautions
Renal and hepatic impairment; narrow-angle glaucoma; epilepsy; prostatic hypertrophy; bladder neck obstruction; asthma; COPD. May impair ability to drive or operate machinery.
Lactation: Excretion in milk unknown; use with caution
Pregnancy-Lactation
Interactions
Additive or may potentiate CNS depressant effects of opiates or other analgesics, barbiturates or other sedatives, and anaesth. MAOIs and TCAs potentiate antimuscarinic effects.
Adverse Effects
Side effects of Hydroxyzine Hydrochloride :
Dizziness, ataxia, fatigue, drowsiness, hallucination, seizure, dry mouth, nervousness, xerostomia, involuntary movements, slurred speech, headache, paraesthesia, tremor, blurred vision, resp depression, pruritus, rash, urticaria, allergic reaction.
Mechanism of Action
Hydroxyzine, a piperazine derivative, blocks histamine H1-receptors on effector cells of the GI tract, blood vessels and resp tract. It is a sedating antihistamine w/ antimuscarinic and significant sedative properties. It also possesses skeletal muscle relaxing, bronchodilator, antiemetic and analgesic properties.
Note
PRU 100ML Syrup manufactured by Yash Pharma Laboratories Pvt. Ltd.. Its generic name is Hydroxyzine Hydrochloride. PRU is availble in Nepal.
Farmaco Nepal drug index information on PRU Syrup is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.