Zanid Tablet

Tizanidine
2mg
Time Pharmaceuticals Pvt. Ltd.
Pack size 10's
Dispensing mode
Source
Agent
Retail Price 8.00 NPR

Indications

Zanid Tablet is used for: Spasticity, Painful muscle spasm

Adult Dose

Oral Muscle Spasticity Spasticity associated with multiple sclerosis and spinal cord injury Initial: 2 mg q6-8hr; no more than 3 doses q24hr Maintenance: Increase by 2 to 4 mg until satisfactory response is achieved with minimum 1-4 days between dose increments Not to exceed 36 mg/day Painful muscle spasm associated with musculoskeletal conditions Adult: 2-4 mg tid. Elderly: Not recommended. Hepatic impairment: Avoid or use with extreme caution.

Child Dose

Child < 18 years: Not recommended

Renal Dose

Renal impairment: CrCl (ml/min) Dosage Recommendation <25 Initially, 2 mg once daily, gradually increasing the dose before increasing the frequency of admin.

Administration

Contra Indications

Severe hepatic dysfunction.

Precautions

Hepatic or renal insufficiency. Children, elderly, pregnancy and lactation. Monitor LFT regularly. Stop treatment if liver enzymes are raised persistently >3 times upper limit of normal range. Avoid abrupt withdrawal of therapy. Lactation: May be excreted in breast milk due to lipophilic nature; use caution

Pregnancy-Lactation

Interactions

Potentiates hypotensive effect of antihypertensives. Increased CNS effects with alcohol and CNS depressants. Increased bradycardia with ?-blockers and digoxin. Increased serum concentration of tizanidine with CYP1A2 inhibitors e.g. zileuton, ciprofloxacin and other fluoroquinolones, antiarrhythmics, cimetidine, famotidine, oral contraceptives, aciclovir and ticlopidine. Decreased serum concentrations of tizanidine with rifampicin. Use with caution with drugs that may prolong QT interval.

Adverse Effects

Side effects of Tizanidine : >10% Dry mouth (46-50%),Somnolence (46-50%),Dizziness (16-20%),Asthenia (10-45%) 1-10% Blurred vision (3%),Constipation (4%),Infection (6%),LFT abnormalities (3-5%),Speech disorder (3%),Vomiting (3%),Urinary frequency (3%),UTI (10%) Frequency Not Defined Asthenia,Bradycardia,Hypotension,Orthostatic hypotension,Syncope (rare) Potentially Fatal: Hepatitis.

Mechanism of Action

Tizanidine, an alpha2-adrenergic agonist, is a centrally acting muscle relaxant structurally related to clonidine. It reduces spasticity by increasing presynaptic inhibition of motor neurons and has no direct effect on skeletal muscle, the neuromuscular junction or on monosynaptic spinal reflexes.

Note

Zanid 2mg Tablet manufactured by Time Pharmaceuticals Pvt. Ltd.. Its generic name is Tizanidine. Zanid is availble in Nepal. Farmaco Nepal drug index information on Zanid Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Tizanidine :