Zati 4 Tablet
Tizanidine
4mg
Asian Pharmaceuticals Pvt. Ltd.
| Pack size | 100'st |
|---|---|
| Dispensing mode | |
| Source | |
| Agent | |
| Retail Price | 15.00 NPR |
Available as:
Indications
Zati 4 Tablet is used for:
Spasticity, Painful muscle spasm
Adult Dose
Oral
Muscle Spasticity
Spasticity associated with multiple sclerosis and spinal cord injury
Initial: 2 mg q6-8hr; no more than 3 doses q24hr
Maintenance: Increase by 2 to 4 mg until satisfactory response is achieved with minimum 1-4 days between dose increments
Not to exceed 36 mg/day
Painful muscle spasm associated with musculoskeletal conditions
Adult: 2-4 mg tid.
Elderly: Not recommended.
Hepatic impairment: Avoid or use with extreme caution.
Child Dose
Child < 18 years: Not recommended
Renal Dose
Renal impairment:
CrCl (ml/min) Dosage Recommendation
<25 Initially, 2 mg once daily, gradually increasing the dose before increasing the frequency of admin.
Administration
Contra Indications
Severe hepatic dysfunction.
Precautions
Hepatic or renal insufficiency. Children, elderly, pregnancy and lactation. Monitor LFT regularly. Stop treatment if liver enzymes are raised persistently >3 times upper limit of normal range. Avoid abrupt withdrawal of therapy.
Lactation: May be excreted in breast milk due to lipophilic nature; use caution
Pregnancy-Lactation
Interactions
Potentiates hypotensive effect of antihypertensives. Increased CNS effects with alcohol and CNS depressants. Increased bradycardia with ?-blockers and digoxin. Increased serum concentration of tizanidine with CYP1A2 inhibitors e.g. zileuton, ciprofloxacin and other fluoroquinolones, antiarrhythmics, cimetidine, famotidine, oral contraceptives, aciclovir and ticlopidine. Decreased serum concentrations of tizanidine with rifampicin. Use with caution with drugs that may prolong QT interval.
Adverse Effects
Side effects of Tizanidine :
>10%
Dry mouth (46-50%),Somnolence (46-50%),Dizziness (16-20%),Asthenia (10-45%)
1-10%
Blurred vision (3%),Constipation (4%),Infection (6%),LFT abnormalities (3-5%),Speech disorder (3%),Vomiting (3%),Urinary frequency (3%),UTI (10%)
Frequency Not Defined
Asthenia,Bradycardia,Hypotension,Orthostatic hypotension,Syncope (rare)
Potentially Fatal: Hepatitis.
Mechanism of Action
Tizanidine, an alpha2-adrenergic agonist, is a centrally acting muscle relaxant structurally related to clonidine. It reduces spasticity by increasing presynaptic inhibition of motor neurons and has no direct effect on skeletal muscle, the neuromuscular junction or on monosynaptic spinal reflexes.
Note
Zati 4 4mg Tablet manufactured by Asian Pharmaceuticals Pvt. Ltd.. Its generic name is Tizanidine. Zati 4 is availble in Nepal.
Farmaco Nepal drug index information on Zati 4 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.