Zepox-10 Tablet
Chlordiazepoxide
10mg
Panas Pharmaceutical Pvt. Ltd.
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Available as:
Indications
Zepox-10 Tablet is used for:
Anxiety, Insomnia, Muscle spasms, Acute symptoms of alcohol withdrawal
Adult Dose
Oral
Insomnia
Adult: 10-30 mg before bedtime.
Muscle spasms
Adult: 10-30 mg daily in divided doses.
Anxiety
Adult: 30 mg daily in divided doses, up to 100 mg daily in severe conditions.
Acute symptoms of alcohol withdrawal
Adult: 25-100 mg daily repeated as necessary. Max dose: 300 mg daily.
Elderly: and debilitated patients: Dose reduction may be needed.
Child Dose
Anxiety
<6 years: Safety and efficacy not established
>6 years: 0.5 mg/kg/day divided PO q6-8hr,
OR 5 mg PO q6-12hr; may increase dose to 10 mg PO q8-12hr
Renal Dose
Renal impairment
CrCl <10 mL/min: 50% of recommended dose
CrCl >10 mL/min: Dose adjustment not necessary (monitor)
Administration
May be taken with or without food.
Contra Indications
Acute pulmonary insufficiency, resp depression, patients with marked neuromuscular resp weakness; hypersensitivity to benzodiazepines; chronic psychosis; porphyria; pregnancy and lactation.
Precautions
Alcohol; sedation, dependence. Elderly and debilitated patients. Liver or kidney dysfunction. Avoid prolonged usage.
Lactation: Enters breast milk/not recommended
Pregnancy-Lactation
Interactions
Cimetidine increases serum conc of chlordiazepoxide. Potentiates action of major neuroleptics.
Potentially Fatal: Alcohol potentiates CNS-depressant effect of chlordiazepoxide.
Adverse Effects
Side effects of Chlordiazepoxide :
>10%
Ataxia,Drowsiness,Memory impairment,Sedation,Muscle weakness,Rash,Decreased libido,Menstrual disorders,Xerostomia,Salivation decreased,Increased/decreased appetite,Weight gain/loss,Micturition difficulties
1-10%
Confusion,Dizziness,Disinhibition,Akathisia,Dermatitis,Hypotension,Salivation increased,Sexual dysfunction,Incontinence,Rigidity,Tremor,Muscle cramps,Tinnitus,Nasal congestion
Mechanism of Action
Chlordiazepoxide enhances activity of the inhibitory transmitter GABA in different parts of CNS by increasing neuronal-membrane permeability to chloride ions resulting to hyperpolarisation and stabilisation. It has some muscle relaxant and anticonvulsant activity.
Note
Zepox-10 10mg Tablet manufactured by Panas Pharmaceutical Pvt. Ltd.. Its generic name is Chlordiazepoxide. Zepox-10 is availble in Nepal.
Farmaco Nepal drug index information on Zepox-10 Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.