Aluminium Oxide + Magnesium Hydroxide + Simethicon
Indications
Aluminium Oxide + Magnesium Hydroxide + Simethicon is used for:
Hyperacidity, Gastric ulcer duodenal ulcer and gastritis
Adult Dose
Chew1-2 tablets or 2-4 tsf after meals and at bedtime as needed (up to 4 times a day).
Child Dose
Renal Dose
Administration
After meals and at bedtime as needed. For best results, drink a half glass of water or other liquid after each dose.
Contra Indications
Hypophosphataemia. Simethicon is contrindicated in renal failure, severely debiliated patients, 1st trimester of pregnancy.
Precautions
Renal dysfunction, low phosphate diet, prolonged use.
Pregnancy-Lactation
Interactions
Aluminium Hydroxide: Enhanced absorption with citrates or ascorbic acid. Decreases absorption of allopurinol, tetracyclines, quinolones, cephalosporins, biphosphonate derivatives, corticosteroids, cyclosporin, delavirdine, Fe salts, imidazole antifungals, isoniazid, mycophenolate, penicillamine, phosphate supplements, phenytoin, phenothiazines, trientine.
Magnesium Hydroxide: Decreases absorption of tetracyclines and biphosphonates. Separate administration of these and other drugs by around 2 hr.
Simethicon: None well documented.
Adverse Effects
Side effects of Aluminium Oxide + Magnesium Hydroxide + Simethicon :
Diarrhoea, constipation, nausea, vomiting.
Mechanism of Action
Aluminum hydroxide: Neutralizes stomach hydrocloride to form AlCl3 salt plus water; increases gastric pH.
Magnesium hydroxide: Promotes bowel evacuation by causing osmotic retention of fluid, which causes the colon to distend with increased peristaltic activity; forms magnesium chloride when reacts with hydrochloric acid.
Simethicone: Disperses and prevents gas pockets in the GI system by decreasing surface tension of gas bubles.