Amoxicillin + Cloxacilin
Indications
Amoxicillin + Cloxacilin is used for:
Susceptible infections
Adult Dose
Oral
Susceptible infections
Adult: Per capsule contains amoxicillin 250 mg and cloxacillin 250 mg: 2-4 caps tid.
Parenteral
Susceptible infections
Adult: Per vial contains amoxicillin 250 mg and cloxacillin 250 mg: 1-2 vials every 6-8 hr. Dose may be given via IM/IV.
Child Dose
Parenteral
Susceptible infections
Child: Per vial contains amoxicillin 250 mg and cloxacillin 250 mg: 1 mth-2 yr: 0.25-0.5 vial every 6-8 hr; 2-10 yr: 0.5-1 vial every 6-8 hr. Dose may be given via IM/IV.
Renal Dose
Administration
Contra Indications
Hypersensitivity to penicillins.
Precautions
Allergy to cephalosporins, infectious mononucleosis, neonates with jaundice, H/o convulsions, lactation.
Pregnancy-Lactation
Interactions
Failure of OC may occur, loss of potency of cloxacillin in soln. reported with erythromycin, gentamicin, kanamycin, colistin, oxytetracycline, chlorpromazine, Vit.C, & polymyxin B sulphate. Products containing cloxacillin should not be added to IV lipids, blood products, protein hydrolysates or other proteinaceous fluids. Chloramphenicol & tetracycline antagonise bactericidal effect of penicillins. Probenecid prolongs serum drug concentration; Sulfonamides & aspirin inhibit serum protein binding of cloxacillin, thereby increasing serum-free drug levels.
Potentially Fatal: None reported.
Adverse Effects
Side effects of Amoxicillin + Cloxacilin :
GI upsets, rash, urticaria, neutropenia, neurotoxicity, agranulocytosis (rarely), increased incidence of phlebitis with IV use.
Potentially Fatal: Rarely anaphylactic shock; pseudomembranous colitis.
Mechanism of Action
Amoxicillin is bactericidal against non β-lactamase producing gm+ve organisms and selected gm-ve pathogens.
Cloxacillin is a beta-lactamase resistant penicillin active against gm+ve organisms including beta-lactamase (penicillinase) producing strains of Staphylococci. It is highly active against Staph aureus, Strep pyogenes, Strep viridans and Strep pneumoniae. Also effective against penicillinase producing gonococci and against N meningitidis and H influenzae.