Amrinone (Inamrinone)

Indications

Amrinone (Inamrinone) is used for: Congestive Heart failure

Adult Dose

Intravenous Heart failure Adult: Loading dose: 750 mcg/kg by slow inj over 2-3 min (may be repeated after 30 minutes if necessary). Maintenance: 5-10 mcg/kg/min by infusion. Max cumulative dose: 10 mg/kg in 24 hr.

Child Dose

Renal Dose

Administration

Contra Indications

Hypersensitivity.

Precautions

Obstructive pulmonary or aortic disease, hypertrophic cardiomyopathy; BP and heart rate monitored during drug administration; fluid and electrolyte balance should be maintained; platelet counts and liver function should be monitored; protect amp from light. Pregnancy and lactation.

Pregnancy-Lactation

Interactions

Chemical interaction with precipitation occurs with amrinone and dextrose or furosemide. Thus drug mixing should be avoided. Potentially Fatal: Concurrent usage with disopyramide may lead to severe hypotension.

Adverse Effects

Side effects of Amrinone (Inamrinone) : GI disturbances, nausea, vomiting, thrombocytopaenia, hypotension, chest pain, hypersensitivity, myositis, vasculitis, nail discoloration, Inj site pain, decreased tear production. Potentially Fatal: Cardiac arrhythmia, hepatotoxicity.

Mechanism of Action

Amrinone is a phosphodiesterase inhibitor which has vasodilating and positive inotropic properties. It causes an increase in cyclic adenosine monophosphate conc leading to greater contractile force in cardiac muscle.