Anidulafungin

Indications

Anidulafungin is used for: Oesophageal candidiasis, Invasive candidiasis, Candidaemia, Candida infections (intra-abdominal abscess, pertonitis)

Adult Dose

Intravenous Oesophageal candidiasis Adult: Loading dose of 100 mg on day 1, then 50 mg once daily thereafter. Continue treatment for at least 14 days and for at least 7 days following resolution of symptoms. To be given by IV infusion. Max infusion rate: 1.1 mg/min. Elderly: No dosage adjustment needed. Intravenous Invasive candidiasis, Candidaemia, Candida infections (intra-abdominal abscess, pertonitis) Adult: Loading dose of 200 mg on day 1, then 100 mg once daily thereafter. Continue treatment for at least 14 days after the last positive culture. To be given by IV infusion. Max infusion rate: 1.1 mg/min. Elderly: No dosage adjustment needed.

Child Dose

Renal Dose

Administration

IV Preparation Aseptically reconstitute each 50 mg vial with 15 mL supplied diluent to obtain a 3.33 mg/mL solution Administer within 24 hr post-reconstitution Dilute further by transferring aseptically in a bag or bottle containing D5W or 0.9% NaCl to provide an infusion solution of 0.5 mg/mL Discard if particulate matter or discoloration appears IV Administration IV infusion rate: Not to exceed 1.1 mg/min Do not give as IV bolus

Contra Indications

Hypersensitivity to anidulafungin or other echinocandins.

Precautions

Patients w/ serious underlying conditions receiving multiple concomitant medications w/ anidulafungin may experience hepatic abnormalities e.g. hepatitis, hepatic dysfunction or worsening hepatic failure. Pregnancy and lactation.

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Anidulafungin : Infusion-related reactions (e.g. pruritus, urticaria, rash, hypotension, dyspnoea, flushing); nausea, diarrhoea; phlebitis/thrombophlebitis, neutropaenia, hypokalaemia, headache; elevated alkaline phosphatase, hepatic enzymes, and γ-glutamyltransferase.

Mechanism of Action

Anidulafungin is a semi-synthetic echinocandin antifungal. Echinocandin - inhibits synthesis of 1,3-beta-D-glucan, an essential component of fungal cell walls.